Rat Protein-tyrosine kinase 2-beta (PTK2B) ELISA Kit
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935106861
info@markelab.com
Precio
687.5€ (96 tests)
Elisa Kits PTK2B
proveedor
Abbexareference
abx391870Tested Applications
ELISAreactivity
Ratstatus
RUOclonality
Descripción
Rat Protein-tyrosine kinase 2-beta (PTK2B) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat PTK2B concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
Protein Tyrosine Kinase 2 Beta (PTK2B), also known as Pyk2, is a cytoplasmic tyrosine kinase related to PTK2 but has distinct roles in calcium signaling, immune responses, and neuronal function. PTK2B is activated by increased intracellular calcium levels, G-protein-coupled receptors (GPCRs), and environmental stress. Structurally, PTK2B shares a similar architecture with PTK2, including an FERM domain, kinase domain, and focal adhesion targeting region, but has a unique sensitivity to calcium signaling. PTK2B regulates cytoskeletal dynamics, cell adhesion, and migration, particularly in immune cells and neurons. PTK2B is highly expressed in the nervous system and plays a pivotal role in synaptic plasticity, neuronal migration, and memory formation. Its overactivation has been linked to neurodegenerative diseases such as Alzheimer’s disease by modulating tau phosphorylation and beta-amyloid signaling. In the immune system, PTK2B influences macrophage activation, B-cell responses, and inflammatory signaling pathways. Dysregulation of PTK2B is also associated with certain cancers, where it promotes cell survival, invasion, and tumor progression. Targeting PTK2B is being explored for potential therapeutic interventions in cancer and neuroinflammation.
Características del producto
category
ELISA Kits
immunogen target
Protein-tyrosine kinase 2-beta (PTK2B)
reactivity
Rat
test range
78 pg/ml - 5000 pg/ml
sensitivity
< 46.9 pg/ml
assay type
Sandwich
assay data
Quantitative
detection method
Colorimetric
sample type
Tissue homogenates,Cell lysates,Other biological fluids
size 1
96 tests
alias
PKB,PTK,CAKB,FAK2,PYK2,CADTK,FADK2,RAFTK,Proline-rich tyrosine kinase 2,Related adhesion focal tyrosine kinase,Calcium-regulated non-receptor proline-rich tyrosine kinase, Cell adhesion kinase beta,CAK-beta,Calcium-dependent tyrosine kinase
storage
Enviado a 4 °C. Una vez recibido, almacene el kit de acuerdo con las instrucciones citadas en el manual del kit
or code
PTK2B
dry ice
No
uniprot id
note
This product is for research use only. <p></p> The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. <p></p> Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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