Rat Platelet Glycoprotein IX (GP9) Protein

Product specifications

Proteins and Peptides

Platelet Glycoprotein IX (GP9)

E. coli

Rat

Unconjugated

Molecular Weight: Calculated MW: 21.4 kDa

Concentration: Prior to lyophilization: 200 µg/ml

Sequence Fragment: Met1-Trp161

Tag: N-terminal His tag

Recombinant

> 95%

10 µg

50 µg

100 µg

200 µg

500 µg

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.

WB, SDS-PAGE

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.

Shipped within 5-7 working days.

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.

No

GPIX,CD42a,Platelet glycoprotein IX,GP-IX,Glycoprotein 9

Protein GP9

RUO

This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

Glycoprotein IX Platelet (GP9), also known as CD42a, is a critical component of the glycoprotein Ib-IX-V complex, which is essential for platelet adhesion and aggregation in the hemostatic process. GP9 is a small transmembrane glycoprotein predominantly expressed on the surface of platelets and megakaryocytes. It associates with glycoprotein Ib alpha (GPIbα), glycoprotein Ib beta (GPIbβ), and glycoprotein V (GPV) to form the functional receptor complex responsible for binding von Willebrand factor (vWF) under conditions of vascular injury and high shear stress. This interaction facilitates platelet adhesion to exposed subendothelial surfaces, initiating clot formation. Mutations in the GP9 gene can lead to Bernard-Soulier syndrome, a rare autosomal recessive disorder characterized by macrothrombocytopenia and defective platelet adhesion. Due to its involvement in thrombosis and hemostasis, GP9 has been studied as a potential therapeutic target in managing thrombotic disorders and cardiovascular diseases. Additionally, its expression levels serve as a marker for platelet maturation and megakaryocyte development.

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The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis. GP-IX may provide for membrane insertion and orientation of GP-Ib.

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GP9 Antibody is a Rabbit Polyclonal antibody against GP9. This gene encodes a small membrane glycoprotein found on the surface of human platelets. It forms a 1-to-1 noncovalent complex with glycoprotein Ib, a platelet surface membrane glycoprotein complex that functions as a receptor for von Willebrand factor. The complete receptor complex includes noncovalent association of the alpha and beta subunits with the protein encoded by this gene and platelet glycoprotein V. Defects in this gene are a cause of Bernard-Soulier syndrome, also known as giant platelet disease. These patients have unusually large platelets and have a clinical bleeding tendency.

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Platelet Glycoprotein IX (GP9) Antibody

This gene encodes a small membrane glycoprotein found on the surface of human platelets. It forms a 1-to-1 noncovalent complex with glycoprotein Ib, a platelet surface membrane glycoprotein complex that functions as a receptor for von Willebrand factor. The complete receptor complex includes noncovalent association of the alpha and beta subunits with the protein encoded by this gene and platelet glycoprotein V. Defects in this gene are a cause of Bernard-Soulier syndrome, also known as giant platelet disease. These patients have unusually large platelets and have a clinical bleeding tendency. [provided by RefSeq].

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