Rat Platelet Glycoprotein IX (GP9) Protein
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935106861
info@markelab.com
Precio
247€ (10 µg)
Protein GP9
proveedor
Abbexareference
abx168551Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Rat Glycoprotein IX, Platelet Protein is a recombinant Rat protein expressed in E. coli.
Background
Glycoprotein IX Platelet (GP9), also known as CD42a, is a critical component of the glycoprotein Ib-IX-V complex, which is essential for platelet adhesion and aggregation in the hemostatic process. GP9 is a small transmembrane glycoprotein predominantly expressed on the surface of platelets and megakaryocytes. It associates with glycoprotein Ib alpha (GPIbα), glycoprotein Ib beta (GPIbβ), and glycoprotein V (GPV) to form the functional receptor complex responsible for binding von Willebrand factor (vWF) under conditions of vascular injury and high shear stress. This interaction facilitates platelet adhesion to exposed subendothelial surfaces, initiating clot formation. Mutations in the GP9 gene can lead to Bernard-Soulier syndrome, a rare autosomal recessive disorder characterized by macrothrombocytopenia and defective platelet adhesion. Due to its involvement in thrombosis and hemostasis, GP9 has been studied as a potential therapeutic target in managing thrombotic disorders and cardiovascular diseases. Additionally, its expression levels serve as a marker for platelet maturation and megakaryocyte development.
Características del producto
category
Proteins and Peptides
origin
Rat
host
E. coli
immunogen target
Platelet Glycoprotein IX (GP9)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 53.3 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Met1-Asn189 Tag: N-terminal His tag and GST tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
GP9
dry ice
No
availability
Shipped within 5-7 working days.
alias
GPIX,CD42a,Platelet glycoprotein IX,GP-IX,Glycoprotein 9
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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