Rat Plasma Protease C1 Inhibitor (SERPING1) Protein
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Description
Rat Plasma Protease C1 Inhibitor (SERPING1) Protein is a recombinant Rat protein expressed in HEK293 cells.
Documents del producto
Product specifications
| Category | Proteins and Peptides |
| Host | HEK293 cells |
| Origin | Rat |
| Observed MW | Molecular Weight: Calculated MW: 55.33 kDa Observed MW (SDS-PAGE): 65 kDa Sequence Fragment: Met1-Ala504 Tag: C-terminal His tag |
| Expression | Recombinant |
| Purity | >95% (SDS-PAGE) |
| Size 1 | 20 µg |
| Size 2 | 100 µg |
| Form | Lyophilized Reconstitute in sterile H2O. Do not vortex. |
| Tested Applications | SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 5% - 8% Trehalose, Mannitol and 0.01% Tween-80. |
| Availability | Shipped within 5-15 working days. |
| Storage | Store lyophilized between -20 °C and -80 °C. |
| Dry Ice | No |
| UniProt ID | Q6P734 |
| Alias | C1IN,C1NH,HAE1,HAE2,C1INH,Plasma protease C1 inhibitor,C1 esterase inhibitor,C1-inhibiting factor |
| Background | Protein SERPING1 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
SERPING1, also known as C1 esterase inhibitor (C1-INH), is a serine protease inhibitor that plays a critical role in regulating the complement system, a part of the immune response. SERPING1 is primarily responsible for controlling the activation of the C1 complex in the classical pathway of complement activation. Beyond complement regulation, it also inhibits several other proteases involved in the coagulation, fibrinolytic, and kinin-generating systems. SERPING1 mutations or deficiencies are strongly linked to hereditary angioedema (HAE), a potentially life-threatening condition characterized by uncontrolled swelling. SERPING1 is an important therapeutic target in diseases where inappropriate immune activation or excessive protease activity leads to tissue damage or inflammation. It is mainly synthesized in the liver and secreted into the bloodstream, where it circulates and exerts its regulatory effects.
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