Rat Peroxisome Proliferator Activated Receptor Alpha (PPARa) Protein

Este producto es parte de PPAR - peroxisome proliferator activated receptor
Product Graph
247€ (10 µg)

Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.

935106861
info@markelab.com
name
Rat Peroxisome Proliferator Activated Receptor Alpha (PPARa) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx652143
tested applications
WB, SDS-PAGE

Description

Peroxisome Proliferator Activated Receptor Alpha (PPARa) Protein is a Recombinant protein from Rat.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Proteins and Peptides
Immunogen Target
Peroxisome Proliferator Activated Receptor Alpha (PPARa)
Host
E. coli
Origin
Rat
Conjugation
Unconjugated
Observed MW
Molecular Weight: Calculated MW: 47.4 kDa  Observed MW (SDS-PAGE): 47 kDa
Concentration: Prior to lyophilization: 200 µg/ml
Sequence Fragment: Ser280-Leu433
Tag: N-terminal His tag and GST tag
Expression
Recombinant
Purity
> 90%
Size 1
10 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
500 µg
Form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300.
Availability
Shipped within 5-7 working days.
Storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
Q9QYK2
Alias
PPAR,NR1C1,Hppar,PPARalpha,PPAR-alpha,Nuclear receptor subfamily 1 group C member 1
Background
Protein PPARA
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

Peroxisome proliferator activated receptor alpha (PPARA) is a nuclear hormone receptor that plays a critical role in the regulation of lipid metabolism, inflammation, and energy homeostasis PPARA is primarily expressed in tissues involved in fatty acid metabolism, such as the liver, heart, and skeletal muscle, where it regulates the transcription of genes involved in the breakdown of fatty acids and lipids The receptor functions by binding to specific ligands, such as fatty acids and fibrates, which activate PPARA and induce the expression of genes involved in lipid catabolism, mitochondrial biogenesis, and oxidative stress response PPARA is also involved in regulating glucose metabolism and insulin sensitivity, making it a key player in metabolic diseases like diabetes and obesity Dysregulation of PPARA has been linked to various disorders, including cardiovascular diseases, metabolic syndrome, and fatty liver disease PPARA's role in regulating inflammation further highlights its therapeutic potential in conditions characterized by chronic inflammation, including atherosclerosis and neurodegenerative diseases

Related Products

FNab06663

PPARA antibody

Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine(16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2.

Ver Producto
FNab10676

PPARA antibody

Ver Producto
P0645

Recombinant Human PPARA

Ver Producto