Rat Nucleoporin P58/p45 (NUP58) ELISA Kit

Background

Nucleoporin 58 (NUP58) is a significant component of the nuclear pore complex, contributing to the transport of large macromolecules, including RNA and proteins, between the nucleus and the cytoplasm It helps regulate nuclear-cytoplasmic exchange by interacting with other nucleoporins to form the structural framework of the nuclear pore complex NUP58 plays a crucial role in the passage of molecules required for cellular processes such as gene expression, protein synthesis, and cell signaling Its involvement in RNA and ribosomal subunit transport is vital for ensuring efficient protein synthesis, which is necessary for cellular function NUP58 also has roles in regulating cellular stress responses and supporting cell division by maintaining the integrity of nuclear pore transport Dysregulation of NUP58 has been implicated in a variety of diseases, including cancer, where malfunctioning nucleocytoplasmic transport can contribute to tumor progression and metastasis Furthermore, NUP58 helps sustain cellular homeostasis by ensuring that key molecules are correctly localized within the nucleus or cytoplasm, making it an essential player in cellular function