Rat Nuclear Receptor Subfamily 1, Group D, Member 2 (NR1D2) Protein
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
Nuclear Receptor Subfamily 1, Group D, Member 2 Protein is a recombinant Rat protein expressed in E. coli.
Documents del producto
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Nuclear Receptor Subfamily 1, Group D, Member 2 (NR1D2) |
| Host | E. coli |
| Origin | Rat |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 67.3 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Lys249-Pro578 Tag: N-terminal His tag and GST tag |
| Expression | Recombinant |
| Purity | > 90% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | RVR,BD73,EAR-1R,REVERBB,REVERBbeta,Rev-erb alpha-related receptor,V-erbA-related protein 1-related |
| Background | Protein NR1D2 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Nuclear receptor subfamily 1 group D member 2 (NR1D2), also known as Rev-Erbβ, is a closely related homolog of NR1D1, and it also plays a crucial role in regulating circadian rhythms and metabolic homeostasis NR1D2 is involved in controlling the expression of genes that regulate the body’s internal clock, metabolism, and immune responses Similar to NR1D1, NR1D2 acts by repressing the transcription of target genes through binding to specific DNA elements, influencing lipid and glucose metabolism, and modulating inflammatory responses NR1D2 is highly expressed in tissues such as the liver, skeletal muscle, and adipose tissue, where it helps control circadian variations in metabolism and energy expenditure Dysregulation of NR1D2 has been associated with metabolic disorders, including obesity, type 2 diabetes, and fatty liver disease, as well as inflammation-related conditions like autoimmune diseases and cardiovascular disorders In addition to its role in metabolism and immune function, NR1D2’s participation in regulating the circadian rhythm highlights its potential therapeutic value for managing disorders related to disrupted biological clocks, such as sleep disturbances and shift work-induced metabolic abnormalities
Related Products
anti- NR1D2 antibody
Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core clock components ARNTL/BMAL1 and CLOCK. Also regulates genes involved in metabolic functions, including lipid metabolism and the inflammatory response. Acts as a receptor for heme which stimulates its interaction with the NCOR1/HDAC3 corepressor complex, enhancing transcriptional repression. Recognizes two classes of DNA response elements within the promoter of its target genes and can bind to DNA as either monomers or homodimers, depending on the nature of the response element. Binds as a monomer to a response element composed of the consensus half-site motif 5'-[A/G]GGTCA-3' preceded by an A/T-rich 5' sequence(RevRE), or as a homodimer to a direct repeat of the core motif spaced by two nuclegotides(RevDR-2). Acts as a potent competitive repressor of ROR alpha(RORA) function and also negatively regulates the expression of NR1D1. Regulates lipid and energy homeostasis in the skeletal muscle via repression of genes involved in lipid metabolism and myogenesis including: CD36, FABP3, FABP4, UCP3, SCD1 and MSTN. Regulates hepatic lipid metabolism via the repression of APOC3. Represses gene expression at a distance in macrophages by inhibiting the transcription of enhancer-derived RNAs(eRNAs). In addition to its activity as a repressor, can also act as a transcriptional activator. Acts as a transcriptional activator of the sterol regulatory element-binding protein 1(SREBF1) and the inflammatory mediator interleukin-6(IL6) in the skeletal muscle.
Ver Producto
Recombinant Human NR1D2
Ver Producto
Nuclear Receptor Subfamily 1 Group D Member 2 (NR1D2) Antibody
This gene encodes a member of the nuclear hormone receptor family, specifically the NR1 subfamily of receptors. The encoded protein functions as a transcriptional repressor and may play a role in circadian rhythms and carbohydrate and lipid metabolism. Alternatively spliced transcript variants have been described.
Ver Producto