Rat Notch2 (Neurogenic locus notch homolog protein 2) ELISA Kit
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name
Rat Notch2 (Neurogenic locus notch homolog protein 2) ELISA Kit
category
ELISA Kits
provider
FineTest
reference
ER0663
tested applications
ELISA
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Reactivity | Rat |
| Detection Method | Colorimetric |
| Assay Data | 4 hours |
| Assay Type | Sandwich ELISA, Double Antibody |
| Test Range | 0.156-10ng/ml |
| Sensitivity | 0.094ng/ml |
| Size 1 | 96T |
| Tested Applications | ELISA |
| Sample Type | Serum, Plasma, Cell Culture Supernatant, cell or tissue lysate, Other liquid samples |
| Availability | Shipped within 10-14 working days. |
| Storage | 2-8 °C for 12 months |
| UniProt ID | Q9QW30 |
| Alias | AGS2,HJCYS,hN2,notch receptor 2 |
| Background | Elisa kits for NOTCH2 |
| Status | RUO |
NOTCH2 is a key receptor in the Notch signaling pathway that regulates cell proliferation, differentiation, and tissue patterning during development. Ligand binding induces proteolytic cleavage, releasing the NOTCH2 intracellular domain (NICD), which activates transcription of target genes to control cell fate decisions. NOTCH2 is particularly critical for organogenesis, including kidney development, where it regulates nephron formation and podocyte differentiation. Dysregulation of NOTCH2 is linked to various pathologies, including Alagille syndrome, where mutations impair liver, heart, and kidney development. NOTCH2 also plays a role in cancer, where aberrant signaling promotes tumorigenesis, particularly in breast, pancreatic, and biliary tract cancers. Knockout models demonstrate defects in kidney morphogenesis, osteoclast development, and hematopoiesis, highlighting NOTCH2’s essential role in organ development, cellular differentiation, and disease progression.
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