Rat Neural Cell Adhesion Molecule 1 / CD56 (NCAM1) Protein
715€ (50 µg)
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935106861
info@markelab.com
name
Rat Neural Cell Adhesion Molecule 1 / CD56 (NCAM1) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx692278
tested applications
SDS-PAGE
Description
Rat NCAM1 Protein is a recombinant protein from Rat produced in HEK293 Cells. A DNA sequence encoding the rat NCAM1 (P13596-1) (Met1-Thr721) was expressed with a polyhistidine tag at the C-terminus.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | NCAM1 |
| Host | HEK293 cells |
| Origin | Rat |
| Observed MW | Molecular Weight: 79.2 kDa Sequence Fragment: Met1-Thr721 Tag: C-terminal His tag Validity: The validity for this protein is 12 months. |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Size 1 | 50 µg |
| Form | |
| Tested Applications | SDS-PAGE |
| Buffer | Prior to lyophilization: 50 mM Tris, 0.15M NaCl, pH 8.0. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P13596-1 |
| Alias | CD56,NCAM,MSK39,N-CAM-1 |
| Background | Protein NCAM1 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Neural Cell Adhesion Molecule 1 (NCAM1), also known as CD56, is a member of the immunoglobulin (Ig) superfamily and plays a critical role in cell-cell adhesion, neuronal development, and synaptic plasticity. NCAM1 is a transmembrane glycoprotein with alternative splice variants and glycosylation modifications, including polysialic acid (PSA) attachment, which regulates its function. Structurally, NCAM1 consists of five extracellular Ig-like domains, two fibronectin type III domains, a transmembrane domain, and a cytoplasmic tail involved in intracellular signaling. NCAM1 is highly expressed in the nervous system, where it facilitates neuronal migration, axonal growth, and the formation of synaptic connections during development. PSA-modified NCAM1 reduces adhesion and promotes neuronal plasticity. In adults, NCAM1 continues to regulate synapse maintenance, memory formation, and neuroregeneration. It is also expressed in other cell types, including natural killer (NK) cells, where it mediates immune recognition.
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