Rat Myosin Light Chain Kinase (MYLK) CLIA Kit
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Description
Rat Myosin Light Chain Kinase (MYLK) Chemiluminescent Immunoassay (CLIA) Kit is a Sandwich Chemiluminescent Immunoassay (CLIA) Kit for use with Tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Product specifications
| Category | CLIA Kits |
| Immunogen Target | Myosin Light Chain Kinase (MYLK) |
| Reactivity | Rat |
| Detection Method | Chemiluminescent |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Sensitivity | < 0.059 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | CLIA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-20 working days. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| Alias | KRP,AAT7,MLCK,MLCK1,MMIHS,MYLK1,MMIHS1,MYLK-L,smMLCK,MLCK108,MLCK210,MSTP083,Telokin,Kinase-related protein,Myosin light chain kinase smooth muscle |
| Background | CLIA Kits MYLK |
| Status | RUO |
| Note | The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
Myosin light chain kinase (MYLK) is a crucial enzyme responsible for phosphorylating the regulatory light chain of myosin II, a process essential for modulating smooth muscle contraction and cellular motility. MYLK functions by activating the actomyosin complex, enhancing cross-bridge cycling, and facilitating tension generation in response to calcium-calmodulin signaling. It is highly expressed in smooth muscle cells, endothelial cells, and non-muscle tissues, reflecting its versatile roles in physiological processes like vascular tone regulation, cell migration, and maintaining epithelial barrier integrity. Dysregulation of MYLK activity has been implicated in pathological conditions such as hypertension, asthma, and acute lung injury, where excessive or insufficient contractile responses can disrupt normal tissue function. The gene encoding MYLK produces several isoforms, each tailored to specific tissue types and functional demands, further underscoring its adaptability in diverse cellular environments. MYLK's role in dynamic cytoskeletal organization and mechanical force generation makes it a focus of therapeutic research, especially in the context of cardiovascular and inflammatory diseases.
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