Rat Metabotropic Glutamate Receptor 7 (GRM7) ELISA Kit

Este producto es parte de GRM - Glutamate Receptor Metabotropic
Rat Metabotropic Glutamate Receptor 7 (GRM7) ELISA Kit

Pida mas información

935106861

info@markelab.com

Precio

715€ (96 tests)

Elisa kits for GRM7

proveedor

Abbexa

reference

abx526279

Tested Applications

ELISA

reactivity

Rat

status

RUO

clonality

Descripción

Rat Metabotropic Glutamate Receptor 7 (GRM7) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat Metabotropic glutamate receptor 7 concentrations in tissue homogenates, cell lysates and other biological fluids.


Background

GRM7, or mGluR7, is a Group III metabotropic glutamate receptor widely expressed in the central nervous system, including the hippocampus, amygdala, and cerebellum. It functions as a presynaptic autoreceptor, coupling to Gi/o proteins to inhibit adenylate cyclase, decrease cAMP production, and suppress glutamate release. GRM7 plays a key role in synaptic plasticity, neuroprotection, and neuronal excitability, contributing to learning, memory, and emotional regulation. Dysregulation of GRM7 signaling is linked to psychiatric and neurological disorders, including anxiety, depression, schizophrenia, and epilepsy, where imbalanced glutamatergic transmission disrupts synaptic function. GRM7 activation has neuroprotective effects, reducing excitotoxicity and oxidative stress in neurodegenerative conditions. Positive allosteric modulators (PAMs) and selective agonists of GRM7 are being explored as therapeutic agents for anxiety, mood disorders, and epilepsy, highlighting its potential in restoring synaptic balance and neuroprotection.

Características del producto

category

ELISA Kits


immunogen target

Metabotropic Glutamate Receptor 7 (GRM7)


reactivity

Rat


test range

0.156 ng/ml - 10 ng/ml


assay data

Quantitative


form

Lyophilized


detection method

Colorimetric


sample type

Tissue homogenates, cell lysates and other biological fluids.


size 1

96 tests


alias

GRM7,GLUR7,GPRC1G,MGLU7,MGLUR7,NEDSHBA,PPP1R87, mGluR7,mGlu7a receptor


storage

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.


or code

GRM7


dry ice

No


note

This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.


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