Rat Metabotropic Glutamate Receptor 1 (GRM1) ELISA Kit
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935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for GRM1
proveedor
Abbexareference
abx576770Tested Applications
ELISAreactivity
Ratstatus
RUOclonality
Descripción
Rat Metabotropic Glutamate Receptor 1 (GRM1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat GRM1 concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
GRM1, also known as mGluR1, is a G protein-coupled receptor (GPCR) that belongs to the Group I metabotropic glutamate receptors. It is widely expressed in the central nervous system (CNS), particularly in the cerebellum, hippocampus, and cortex, where it regulates excitatory neurotransmission, synaptic plasticity, and intracellular calcium signaling. GRM1 couples to Gq proteins, activating phospholipase C (PLC) and triggering the release of intracellular calcium. It plays a critical role in motor coordination, learning, and memory. Dysregulation of GRM1 has been linked to neurological disorders, including cerebellar ataxia, epilepsy, and neurodegenerative diseases such as Huntington’s disease. In cancer, GRM1 overexpression has been implicated in melanoma progression, where it enhances cell proliferation and survival. GRM1 antagonists are being explored for treating neurological disorders, chronic pain, and cancer, as targeting its signaling pathways can modulate excitatory transmission and cellular growth.
Características del producto
category
ELISA Kits
immunogen target
Metabotropic Glutamate Receptor 1 (GRM1)
reactivity
Rat
test range
0.312 ng/ml - 20 ng/ml
sensitivity
< 0.109 ng/ml
assay type
Sandwich
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
alias
GRM1,GPRC1A,MGLU1,MGLUR1 PPP1R85,SCA44,SCAR13,metabotropic glutamate receptor 1,wob,glutamate receptor metabotropic 1
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
GRM1
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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