Rat Melatonin Receptor 1b (MTNR1B) ELISA Kit
715€ (96 tests)
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935106861
info@markelab.com
name
Rat Melatonin Receptor 1b (MTNR1B) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx533985
tested applications
ELISA
Description
Rat Melatonin Receptor 1b (MTNR1B) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat Melatonin receptor type 1B concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Melatonin Receptor 1b (MTNR1B) |
| Reactivity | Rat |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.625 ng/ml - 40 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | P49287 |
| Alias | MTNR1B,mel1b receptor |
| Background | Elisa kits for MTNR1B |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
MTNR1B, also known as MT2, is a G protein-coupled receptor for melatonin, expressed in the retina, pancreas, and central nervous system. Like MTNR1A, MTNR1B inhibits adenylate cyclase activity through Gi proteins, reducing cAMP levels and modulating circadian rhythms, sleep regulation, and metabolic processes. MTNR1B plays a critical role in glucose metabolism by regulating insulin secretion in pancreatic β-cells, where melatonin signaling affects insulin release and glucose homeostasis. Genetic variants in MTNR1B have been strongly associated with an increased risk of type 2 diabetes, highlighting its role in impaired glucose tolerance and β-cell dysfunction. In the retina, MTNR1B helps regulate photoreceptor sensitivity and circadian rhythms, contributing to visual function. Dysregulation of MTNR1B signaling has been linked to sleep disturbances, metabolic disorders, and impaired glucose regulation. MTNR1B is being explored as a therapeutic target for managing type 2 diabetes, circadian rhythm disorders, and sleep-related conditions, emphasizing its dual role in metabolic and circadian regulation.
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