Rat Matrix Metalloproteinase 9 (MMP-9) Protein
proveedor
Abbexareference
abx691491Tested Applications
SDS-PAGEreactivity
status
RUOclonality
Descripción
Rat MMP-9 Protein is a recombinant protein from Rat produced in HEK293 Cells. A DNA sequence encoding the rat MMP9 (EDL96479.1) (Met 1-Pro 708) was expressed, fused with a polyhistidine tag at the C-terminus.
Background
MMPs are secreted by diverse connective tissue and pro-inflammatory cells. Typically, these enzymes exhibit minimal expression under normal physiological circumstances. MMPs assume a pivotal role in various cellular processes, including cell proliferation, migration, differentiation, angiogenesis, apoptosis, and immunity. They share a common domain structure, consisting of three key components. First is the pro-peptide, which requires removal to activate the enzyme. Next, there is the catalytic domain, featuring a cysteine switch, where a cysteine residue interacts with zinc, and the haemopexin-like C-terminal domain is linked to the catalytic domain via a flexible hinge region. MMP-9, alternatively known as 92 kDa type IV collagenase, 92 kDa gelatinase, or gelatinase B (GELB), belongs to the zinc-metalloproteinases within the Matrixin family. In humans, the MMP-9 gene is responsible for encoding this enzyme. MMP-9's substrates include gelatin and collagen types IV and V. This gelatinase, MMP-9, has been associated with various medical conditions, including the development of atherosclerosis, chronic obstructive pulmonary disease (COPD), tumor formation, metastasis, and wound repair
Características del producto
category
Proteins and Peptides
origin
Rat
host
HEK293 cells
immunogen target
MMP-9
host
HEK293 cells
tested applications
SDS-PAGE
size 1
50 µg
expression
Recombinant
purity
> 95% (SDS-PAGE)
buffer
Lyophilized from sterile 50mM MES, 100mM NaCl, 1mM CaCl2, 10% Glycerol, pH 7.4.
storage
Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles.
or code
MMP9
dry ice
No
availability
Shipped within 5-15 working days.
alias
GELB,CLG4B,MMP-9,MANDP2,92 kDa type IV collagenase, Gelatinase B
NCBI accession
EDL96479.1
note
This product is for research use only. <p></p> Not for human consumption, cosmetic, therapeutic or diagnostic use.
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