Rat MMP-9 Protein is a recombinant protein from Rat produced in HEK293 Cells. A DNA sequence encoding the rat MMP9 (EDL96479.1) (Met 1-Pro 708) was expressed, fused with a polyhistidine tag at the C-terminus.
MMPs are secreted by diverse connective tissue and pro-inflammatory cells. Typically, these enzymes exhibit minimal expression under normal physiological circumstances. MMPs assume a pivotal role in various cellular processes, including cell proliferation, migration, differentiation, angiogenesis, apoptosis, and immunity. They share a common domain structure, consisting of three key components. First is the pro-peptide, which requires removal to activate the enzyme. Next, there is the catalytic domain, featuring a cysteine switch, where a cysteine residue interacts with zinc, and the haemopexin-like C-terminal domain is linked to the catalytic domain via a flexible hinge region. MMP-9, alternatively known as 92 kDa type IV collagenase, 92 kDa gelatinase, or gelatinase B (GELB), belongs to the zinc-metalloproteinases within the Matrixin family. In humans, the MMP-9 gene is responsible for encoding this enzyme. MMP-9's substrates include gelatin and collagen types IV and V. This gelatinase, MMP-9, has been associated with various medical conditions, including the development of atherosclerosis, chronic obstructive pulmonary disease (COPD), tumor formation, metastasis, and wound repair
Proteins and Peptides
Rat
HEK293 cells
MMP-9
HEK293 cells
SDS-PAGE
50 µg
Recombinant
> 95% (SDS-PAGE)
Lyophilized from sterile 50mM MES, 100mM NaCl, 1mM CaCl2, 10% Glycerol, pH 7.4.
Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles.
MMP9
No
Shipped within 5-15 working days.
GELB,CLG4B,MMP-9,MANDP2,92 kDa type IV collagenase, Gelatinase B
EDL96479.1
This product is for research use only. <p></p> Not for human consumption, cosmetic, therapeutic or diagnostic use.
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