Rat Mast/Stem Cell Growth Factor Receptor Kit (KIT) Protein

Este producto es parte de KIT - KIT receptor tyrosine kinase ( proto oncogene)
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1235€ (100 µg)

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935106861
info@markelab.com
name
Rat Mast/Stem Cell Growth Factor Receptor Kit (KIT) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx691232
tested applications
SDS-PAGE

Description

Rat KIT Protein is a recombinant protein from Rat produced in HEK293 Cells. A DNA sequence encoding the rat KIT (Q63116) (Met1-Thr522) was expressed, fused with the Fc region of human IgG1 at the C-terminus.

Documents del producto

Instrucciones
Data sheet
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Product specifications

Category
Proteins and Peptides
Immunogen Target
Mast/Stem Cell Growth Factor Receptor Kit (KIT)
Host
HEK293 cells
Origin
Rat
Observed MW
Molecular Weight: 82.4 kDa
Sequence Fragment: Met1-Thr522
Tag: C-terminal Fc tag
Validity: The validity for this protein is 12 months.
Expression
Recombinant
Purity
> 95% (SDS-PAGE)
Size 1
100 µg
Form
 
Tested Applications
SDS-PAGE
Buffer
Lyophilized from sterile PBS, pH 7.4.
Availability
Shipped within 5-15 working days.
Storage
Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
Q63116
Alias
Mast/stem cell growth factor receptor Kit,PBT,SCFR,C-Kit,CD117,MASTC,Piebald trait protein (PBT),Proto-oncogene c-Kit,Proto-oncogene c-Kit,p145 c-kit,v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
Background
Protein KIT
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

The KIT protein, also known as the KIT receptor tyrosine kinase or CD117, is a proto-oncogene that encodes a transmembrane receptor. It plays essential roles in cell growth, survival, migration, and differentiation in several types of cells, especially in hematopoietic stem cells, germ cells, melanocytes, and cells in the gastrointestinal tract. The gene encoding KIT is located on chromosome 4q12 and is highly conserved across species, highlighting its fundamental role in development and cellular homeostasis. KIT is activated by binding to its ligand, stem cell factor (SCF), also known as mast cell growth factor. This binding triggers a cascade of downstream signaling pathways critical for normal cellular processes. However, mutations in KIT can result in its constitutive activation, which is implicated in various diseases, including gastrointestinal stromal tumors (GISTs), systemic mastocytosis, acute myeloid leukemia (AML), and other cancers. As a proto-oncogene, KIT’s aberrant signaling due to mutation can drive tumorigenesis, making it a target for cancer therapies, particularly tyrosine kinase inhibitors (TKIs).

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