Rat Lysosomal Associated Membrane Protein 1 (LAMP1) Protein
1079€ (100 µg)
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935106861
info@markelab.com
name
Rat Lysosomal Associated Membrane Protein 1 (LAMP1) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx691114
tested applications
SDS-PAGE
Description
Rat LAMP1 Protein is a recombinant protein from Rat produced in HEK293 Cells. A DNA sequence encoding the Rat LAMP1 (P14562) (Met1-Asn371) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | LAMP1 |
| Host | HEK293 cells |
| Origin | Rat |
| Observed MW | Molecular Weight: 65.1 kDa Sequence Fragment: Met1-Asn371 Tag: C-terminal Fc tag Validity: The validity for this protein is 12 months. |
| Expression | Recombinant |
| Purity | > 92% (SDS-PAGE) |
| Size 1 | 100 µg |
| Form | |
| Tested Applications | SDS-PAGE |
| Buffer | Lyophilized from sterile PBS, pH 7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P14562 |
| Alias | LAMPA,CD107a,LGP120,CD107 antigen-like family member A |
| Background | Protein LAMP1 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Lysosome-associated membrane glycoprotein 1 (LAMP1) is a transmembrane protein located on the lysosomal membrane that plays a key role in lysosome integrity, autophagy, and cellular homeostasis LAMP1 is highly expressed in cells undergoing autophagy, where it contributes to lysosomal stability and fusion with autophagosomes for the degradation of cellular waste It is involved in lysosome exocytosis, which regulates plasma membrane repair, pathogen clearance, and cellular stress responses LAMP1 also serves as a marker for lysosomal activity and has been implicated in immune responses, particularly in natural killer (NK) cell-mediated cytotoxicity Dysregulation of LAMP1 expression has been observed in neurodegenerative diseases such as Parkinson’s and Alzheimer’s, where impaired lysosomal function leads to protein aggregation and cellular toxicity Additionally, LAMP1 overexpression is associated with cancer progression and metastasis, where it facilitates cellular invasion through lysosome-mediated extracellular matrix degradation Its role in maintaining lysosomal function underscores its importance in cellular health and disease pathology
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