Rat Lysosome-Associated Membrane Glycoprotein 1 (LAMP1) Protein
1118€ (100 µg)
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Name
Rat Lysosome-Associated Membrane Glycoprotein 1 (LAMP1) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx691114
Tested Applications
SDS-PAGE
Description
Lysosome-Associated Membrane Glycoprotein 1 (LAMP1) protein is a recombinant Rat protein expressed in HEK293 cells.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Lysosome-Associated Membrane Glycoprotein 1 (LAMP1) |
| Host | HEK293 cells |
| Assay Type | Activity: Not tested Sequence Fragment: Met1-Asn371 Tag: C-terminal Fc tag |
| Origin | Rat |
| Observed MW | 65.1 kDa |
| Expression | Recombinant |
| Purity | > 92% (SDS-PAGE) |
| Size 1 | 100 µg |
| Form | Lyophilized |
| Tested Applications | SDS-PAGE |
| Buffer | Prior to lyophilization: Sterile PBS, pH 7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Storage: Store lyophilized between -20 °C and -80°C. Stability: Stable when stored reconstituted at 2-8°C for up to 1 week. Reconstituted aliquots are stable at -20°C for up to 3 months. Shelf Life: 12 months. |
| Dry Ice | No |
| UniProt ID | P14562 |
| Alias | LAMPA,CD107a,LGP120,CD107 antigen-like family member A |
| Background | Protein LAMP1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. Endotoxin Level: < 1.0 EU per µg (LAL method). |
Background
Lysosome-associated membrane glycoprotein 1 (LAMP1) is a transmembrane protein located on the lysosomal membrane that plays a key role in lysosome integrity, autophagy, and cellular homeostasis LAMP1 is highly expressed in cells undergoing autophagy, where it contributes to lysosomal stability and fusion with autophagosomes for the degradation of cellular waste It is involved in lysosome exocytosis, which regulates plasma membrane repair, pathogen clearance, and cellular stress responses LAMP1 also serves as a marker for lysosomal activity and has been implicated in immune responses, particularly in natural killer (NK) cell-mediated cytotoxicity Dysregulation of LAMP1 expression has been observed in neurodegenerative diseases such as Parkinson’s and Alzheimer’s, where impaired lysosomal function leads to protein aggregation and cellular toxicity Additionally, LAMP1 overexpression is associated with cancer progression and metastasis, where it facilitates cellular invasion through lysosome-mediated extracellular matrix degradation Its role in maintaining lysosomal function underscores its importance in cellular health and disease pathology
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