Rat Low Affinity Immunoglobulin Epsilon Fc Receptor / CD23 (FCER2) Protein
1079€ (100 µg)
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935106861
info@markelab.com
name
Rat Low Affinity Immunoglobulin Epsilon Fc Receptor / CD23 (FCER2) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx693066
tested applications
SDS-PAGE
Description
Rat CD23 Protein is a recombinant protein from Rat produced in HEK293 Cells. A DNA sequence encoding the rat FCER2 (Q6AZ45) (Glu50-Pro331) was expressed with Fc region of human IgG1 at the N-terminus.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | CD23 |
| Host | HEK293 cells |
| Origin | Rat |
| Observed MW | Molecular Weight: 60.2 kDa Sequence Fragment: Glu50-Pro331 Tag: N-terminal Fc tag Validity: The validity for this protein is 12 months. |
| Expression | Recombinant |
| Purity | > 90% (SDS-PAGE) |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | |
| Tested Applications | SDS-PAGE |
| Buffer | Lyophilized from sterile PBS, PH 7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q6AZ45 |
| Alias | CD23,FCE2,CD23A,IGEBF,CLEC4J,FCErII,BLAST-2,Low affinity immunoglobulin epsilon Fc receptor,C-type lectin domain family 4 member J,Fc-epsilon-RII,Immunoglobulin E-binding factor,Lymphocyte IgE receptor |
| Background | Protein FCER2 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
FCER2, also known as CD23, is a low-affinity receptor for the Fc region of Immunoglobulin E (IgE). It is an important protein involved in the regulation of IgE-mediated immune responses and plays a key role in allergy, asthma, and immune regulation. FCER2 was first recognized for its role in B cell differentiation and later found to be expressed in several other immune cell types, including monocytes, eosinophils, dendritic cells, and macrophages. The interaction of CD23 with IgE is critical in the regulation of IgE levels and in modulating allergic responses. Unlike Fc epsilon receptor I (FCERI), which is a high-affinity receptor for IgE and is found on mast cells and basophils, CD23 has a much lower affinity for IgE and is expressed predominantly on B cells. This difference in affinity and cellular distribution allows CD23 to play a different role in immune regulation, particularly in controlling the production of IgE and mediating the interaction between IgE and antigen-presenting cells.
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