Rat Linker For Activation of T-Cells Family Member 2 (LAT2) ELISA Kit
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935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for LAT2
proveedor
Abbexareference
abx536025Tested Applications
ELISAreactivity
Ratstatus
RUOclonality
Descripción
Rat Linker For Activation of T-Cells Family, Member 2 (LAT2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat Linker for activation of T-cells family member 2 concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
Linker for activation of T-cells family member 2 (LAT2), also known as NTAL (Non-T cell Activation Linker), is an adaptor protein expressed in various immune cells, including B cells, mast cells, and NK cells. LAT2 functions analogously to LAT by facilitating signal transduction from immunoreceptors, such as the B-cell receptor (BCR) and Fc receptors, to downstream signaling cascades. Upon receptor engagement, LAT2 undergoes tyrosine phosphorylation, enabling it to recruit signaling molecules, such as Grb2 and PLCγ, which are essential for calcium mobilization and activation of the MAPK pathway. LAT2 plays a crucial role in immune responses, particularly in B-cell activation, mast cell degranulation, and cytokine production. Unlike LAT, LAT2 exhibits a broader expression pattern and participates in both adaptive and innate immunity. Its dysregulation has been implicated in allergic reactions and immune cell hyperactivity, making it a potential therapeutic target in allergic and inflammatory diseases.
Características del producto
category
ELISA Kits
immunogen target
Linker For Activation of T-Cells Family Member 2 (LAT2)
reactivity
Rat
test range
0.156 ng/ml - 10 ng/ml
sensitivity
< 0.07 ng/ml
assay type
Sandwich
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates, cell culture supernatants and other biological fluids.
size 1
96 tests
size 2
5 × 96 tests
size 3
10 × 96 tests
alias
LAT2,LAB, NTAL, WBSCR15, WBSCR5, WSCR5, HSPC046
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
LAT2
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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