Rat Interleukin 9 Receptor (IL9R) Protein
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Description
Rat IL9R Protein is a recombinant protein from Rat produced in HEK293 Cells. A DNA sequence encoding the rat IL9R / Interleukin 9 receptor (EDM04022.1) extracellular domain (Met 1-Ala 270) was expressed, fused with a polyhistidine tag at the C-terminus.
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Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | IL9R |
| Host | HEK293 cells |
| Origin | Rat |
| Observed MW | Molecular Weight: 28.2 kDa Sequence Fragment: Met1-Ala270 Tag: C-terminal His tag Validity: The validity for this protein is 12 months. |
| Expression | Recombinant |
| Purity | > 90% (SDS-PAGE) |
| Size 1 | 50 µg |
| Form | |
| Tested Applications | SDS-PAGE |
| Buffer | Lyophilized from sterile PBS, pH 7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| NCBI Accession | EDM04022.1 |
| Alias | CD129,IL-9R,IL-9 receptor |
| Background | Protein IL9R |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
The interleukin-9 receptor (IL9R) is a key component of the immune system, primarily involved in mediating the biological activities of interleukin-9 (IL-9), a cytokine secreted by T helper 2 (Th2) cells, mast cells, and a subset of T helper cells known as Th9 cells. IL-9 is known for its pleiotropic effects, influencing various cell types including mast cells, T cells, B cells, and epithelial cells. It is particularly important in immune responses, inflammatory processes, and allergic reactions. IL9R, through binding IL-9, initiates signaling cascades that play critical roles in the regulation of cell survival, proliferation, and differentiation in immune responses. The IL9R gene is located on the X chromosome (Xq28) in humans, which makes certain IL9R-related mutations have potential X-linked patterns of inheritance. Notably, IL9R signaling is involved in allergic diseases, asthma, and certain cancers. Additionally, IL-9 and IL9R have been implicated in autoimmune diseases and responses to infections, such as helminth infections. Due to its versatile role in immunity, IL9R is an area of interest for therapeutic strategies aiming to modulate immune responses, particularly in allergy and asthma, and cancer treatment.
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