Rat Interleukin 7 Receptor (IL7R) Protein (Active)
715€ (50 µg)
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935106861
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name
Rat Interleukin 7 Receptor (IL7R) Protein (Active)
category
Proteins and Peptides
provider
Abbexa
reference
abx690883
tested applications
SDS-PAGE
Description
Rat IL7R Protein is a recombinant protein from Rat produced in HEK293 Cells. A DNA sequence encoding the rat IL7R (D4A3X8) (Met1-Asp239) was fused with Fc region of mouse IgG at the C-terminus.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | IL7R |
| Host | HEK293 cells |
| Origin | Rat |
| Observed MW | Molecular Weight: 51.4 kDa Sequence Fragment: Met1-Asp239 Tag: C-terminal Fc tag Validity: The validity for this protein is 12 months. |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Size 1 | 50 µg |
| Form | |
| Tested Applications | SDS-PAGE |
| Buffer | Lyophilized from sterile PBS, pH 7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | Interleukin-7 receptor subunit alpha,ILRA,CD127,IL7RA,CDW127,IMD104,sIL-7R,lnc-IL7R,IL7Ralpha,IL-7Ralpha,IL-7R-alpha,IL-7 receptor subunit alpha; IL-7R subunit alpha,IL-7RA |
| Background | Protein IL7R |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
The interleukin-7 receptor (IL7R) is a critical component of immune system regulation, playing a major role in the development, survival, and homeostasis of T cells and, to a lesser extent, B cells. It is encoded by the IL7R gene and consists of two distinct subunits: IL-7Rα (CD127), which is unique to the IL-7 receptor, and γc (CD132), a common gamma chain shared with other cytokine receptors such as those for IL-2, IL-4, IL-9, IL-15, and IL-21. IL-7, the ligand for IL7R, is an essential cytokine that provides survival signals to developing lymphocytes and regulates their function, influencing T cell diversity, immune tolerance, and immune responsiveness. The IL7R signaling pathway has profound effects on immune system homeostasis, enabling it to counteract immune deficiencies, support immune recovery after depletion, and maintain immune memory. Dysregulation of IL7R, however, is implicated in a range of conditions, including severe combined immunodeficiency (SCID), autoimmune diseases, and certain cancers, especially T-cell acute lymphoblastic leukemia. The receptor’s pivotal role in lymphocyte biology makes it a significant target for immunological therapies and interventions.
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