Rat Interleukin 2 Receptor Alpha (IL2RA) Protein

Este producto es parte de IL2RA - interleukin 2 receptor subunit alpha
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247€ (10 µg)

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935106861
info@markelab.com
name
Rat Interleukin 2 Receptor Alpha (IL2RA) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx067495
tested applications
WB, SDS-PAGE

Description

Recombinant Interleukin 2 Receptor Alpha (IL2Ra) is a recombinant Rat protein produced in a Prokaryotic expression system (E. coli).

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Proteins and Peptides
Immunogen Target
Interleukin 2 Receptor Alpha (IL2RA)
Host
E. coli
Origin
Rat
Conjugation
Unconjugated
Observed MW
Molecular Weight: Calculated MW: 25.3 kDa  Observed MW (SDS-PAGE): 27 kDa

Concentration: Prior to lyophilization: 200 µg/ml

Sequence Fragment: Cys24-Met225

Tag: N-terminal His tag
Expression
Recombinant
Purity
> 95%
Size 1
10 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
500 µg
Form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
Availability
Shipped within 5-7 working days.
Storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
P26897
Alias
p55,CD25,IL2R,IMD41,TCGFR,IDDM10,Interleukin-2 receptor subunit alpha,IL-2 receptor subunit alpha; IL-2-RA; IL-2R subunit alpha; IL2-RA,TAC antigen
Background
Protein IL2RA
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

Interleukin 2 receptor subunit alpha (IL2RA), also known as CD25, is a crucial component of the high-affinity interleukin-2 (IL-2) receptor complex, which is essential for regulating immune responses, particularly T-cell proliferation and survival. The IL-2 receptor plays a pivotal role in both adaptive immunity and immune tolerance, with IL2RA being one of the three subunits that form the IL-2 receptor complex. The IL-2 receptor system is critically involved in the regulation of T-cell homeostasis, immune activation, and the suppression of autoimmunity. IL2RA is primarily expressed on activated T cells, particularly regulatory T cells (Tregs), which are crucial for maintaining immune tolerance. It is also found on other immune cells, including activated B cells, dendritic cells, and natural killer (NK) cells under certain conditions. Importantly, IL2RA expression is tightly regulated, being upregulated upon T-cell activation and playing a central role in fine-tuning immune responses.

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