Rat Interleukin 12B (IL12B) CLIA Kit
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Description
Rat Interleukin 12B (IL12B) Chemiluminescent Immunoassay (CLIA) Kit is a Sandwich Chemiluminescent Immunoassay (CLIA) Kit for use with Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.
Documents del producto
Product specifications
| Category | CLIA Kits |
| Immunogen Target | Interleukin 12B (IL12B) |
| Reactivity | Rat |
| Detection Method | Chemiluminescent |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 15.6 pg/ml - 1000 pg/ml |
| Sensitivity | < 5.8 pg/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | CLIA |
| Sample Type | Serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids. |
| Availability | Shipped within 5-20 working days. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| Alias | CLMF,NKSF,CLMF2,IMD28,IMD29,NKSF2,IL-12B,Cytotoxic lymphocyte maturation factor 40 kDa subunit,CLMF p40,IL-12 subunit p40,NK cell stimulatory factor chain 2 |
| Background | CLIA Kits IL12B |
| Status | RUO |
| Note | The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
Interleukin 12 beta (IL12B), also referred to as IL-12p40, is another key subunit of interleukin-12 and is critical for immune regulation and pathogen defense. IL12B pairs with IL12A to form IL-12 or with IL23A to form IL-23, a related cytokine involved in promoting inflammation and autoimmunity. Produced primarily by antigen-presenting cells in response to microbial infections or inflammatory stimuli, IL12B drives the differentiation of naïve CD4+ T-cells into Th1 cells, promoting IFN-γ secretion and enhancing immune responses against intracellular pathogens. Genetic variations in IL12B have been linked to increased susceptibility to autoimmune disorders, such as psoriasis and inflammatory bowel disease (IBD). As a result, IL12B is a target of therapeutic interest in immune-mediated diseases, and IL-12/IL-23 inhibitors have been developed to treat conditions like psoriasis and Crohn's disease. Understanding the intricate regulation and functional roles of IL12B remains a priority in immunological research.
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