Rat Interleukin 12 (IL12) Protein
481€ (20 µg)
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935106861
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name
Rat Interleukin 12 (IL12) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx694296
tested applications
SDS-PAGE
Description
Rat Interleukin 12 (IL12) Protein is a recombinant Rat protein expressed in HEK293 cells.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Host | HEK293 cells |
| Origin | Rat |
| Observed MW | Molecular Weight: Calculated MW: 36.7&22.6 kDa Observed MW (SDS-PAGE): 25-35&40-50 kDa Sequence Fragment: Met23-Ser335 Tag: C-terminal His tag |
| Expression | Recombinant |
| Purity | >95% (SDS-PAGE) |
| Purification | 0.2 μm filtered prior to lyophilization. |
| Size 1 | 20 µg |
| Size 2 | 100 µg |
| Form | Lyophilized Reconstitute in sterile H2O. Do not vortex. |
| Tested Applications | SDS-PAGE |
| Buffer | Prior to lyophilization: 20 mM PB, 150 mM NaCl, pH 7.4, containing 5% - 8% Trehalose, Mannitol and 0.01% Tween-80. |
| Availability | Shipped within 5-15 working days. |
| Storage | Store lyophilized between -20 °C and -80 °C. |
| Dry Ice | No |
| UniProt ID | Q9R278, Q9R103 |
| Alias | P35,CLMF,NFSK,NKSF1,IL-12A,Cytotoxic lymphocyte maturation factor 35 kDa subunit,CLMF p35,IL-12 subunit p35,NK cell stimulatory factor chain 1 |
| Background | Protein IL12A |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Interleukin 12A (IL12A) is a subunit of the heterodimeric cytokine interleukin-12, which plays a pivotal role in the immune system by bridging innate and adaptive immunity. IL12A, also known as IL-12p35, pairs with the IL12B subunit (IL-12p40) to form the active cytokine IL-12, which is essential for inducing T-helper 1 (Th1) immune responses. IL12A is produced by activated antigen-presenting cells, such as macrophages and dendritic cells, in response to infections or immune challenges. It functions by stimulating natural killer (NK) cells and CD4+ T-cells to produce interferon-gamma (IFN-γ), a cytokine critical for pathogen clearance and enhancing cytotoxic activities. Dysregulation of IL12A expression has been associated with autoimmune diseases, chronic inflammation, and cancer. Therapeutic strategies targeting IL12A, including IL-12 inhibitors or engineered cytokines, are being explored for managing these conditions and for enhancing anti-tumor immune responses.
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