Rat Interleukin 1 Receptor Type I (IL1R1) Protein
416€ (50 µg)
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935106861
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name
Rat Interleukin 1 Receptor Type I (IL1R1) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx651369
tested applications
WB, SDS-PAGE
Description
Interleukin 1 Receptor Type I (IL1R1) Protein (Active) is an active protein from Rat.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Interleukin 1 Receptor Type I (IL1R1) |
| Host | E. coli |
| Origin | Rat |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 12.7 kDa Observed MW: 13 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Thr119-Tyr217 Tag: N-terminal His tag |
| Purity | > 97% |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 500 µg |
| Size 5 | 1 mg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | IL1R1,CD121a, IL1 RI |
| Background | Protein IL1R1 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
IL1R1 is a transmembrane receptor that belongs to the interleukin-1 receptor family and plays a central role in mediating pro-inflammatory signaling IL1R1 binds to interleukin-1α (IL-1α), interleukin-1β (IL-1β), and the IL-1 receptor antagonist (IL-1Ra), forming a receptor complex with the IL-1 receptor accessory protein (IL1RAP) to initiate downstream signaling Upon ligand binding, IL1R1 activates intracellular pathways such as nuclear factor kappa B (NF-κB) and mitogen-activated protein kinases (MAPKs), leading to the expression of pro-inflammatory cytokines, chemokines, and adhesion molecules IL1R1 is expressed on various immune and non-immune cells, including macrophages, fibroblasts, and epithelial cells, where it mediates immune responses to infection, injury, and inflammation Dysregulation of IL1R1 signaling is implicated in chronic inflammatory diseases such as rheumatoid arthritis, inflammatory bowel disease, and systemic lupus erythematosus IL1R1 is also a target for anti-inflammatory therapies, including drugs like anakinra, which block IL-1 binding to reduce inflammation and disease progression
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