Rat Inducible T-Cell Costimulator (ICOS) Protein

Este producto es parte de ICOS - inducible T cell costimulator
Rat Inducible T-Cell Costimulator (ICOS) Protein

Pida mas información

935106861

info@markelab.com

Precio

221€ (10 µg)

Protein ICOS

proveedor

Abbexa

reference

abx067184

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Inducible T-Cell Co Stimulator (ICOS) is a recombinant Rat protein produced in a Prokaryotic expression system (E. coli).


Background

Inducible T-cell costimulator (ICOS), a member of the CD28 family of costimulatory receptors, is expressed on activated T cells and plays a crucial role in modulating immune responses. ICOS, encoded by the ICOS gene, provides an essential costimulatory signal that promotes T cell activation, differentiation, and cytokine production. Upon activation by its ligand, ICOS ligand (ICOSLG or CD275), which is found on antigen-presenting cells (APCs) like B cells, dendritic cells, and macrophages, ICOS triggers intracellular signaling pathways that enhance T-cell effector functions. ICOS is crucial for both humoral and cell-mediated immunity. It enhances T-helper cell responses, particularly in the germinal centers of lymphoid tissues, where it influences B cell differentiation and supports antibody production. ICOS signaling also helps maintain the balance between effector and regulatory T cells, impacting inflammation control and immune tolerance. The ICOS/ICOSLG pathway is vital in the immune system's ability to fight infection and respond to vaccination, as well as in controlling immune tolerance to prevent autoimmune diseases.

Características del producto

category

Proteins and Peptides


origin

Rat


host

E. coli


immunogen target

Inducible T-Cell Costimulator (ICOS)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 12.2 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Gln39-Glu133 Tag: N-terminal His tag


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

ICOS


dry ice

No


availability

Shipped within 5-12 working days.


alias

Activation-inducible lymphocyte immunomediatory molecule,AILIM,CD278,CVID1,


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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