Rat Inducible T-Cell Costimulator (ICOS) Protein
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935106861
info@markelab.com
Precio
221€ (10 µg)
Protein ICOS
proveedor
Abbexareference
abx067184Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Inducible T-Cell Co Stimulator (ICOS) is a recombinant Rat protein produced in a Prokaryotic expression system (E. coli).
Background
Inducible T-cell costimulator (ICOS), a member of the CD28 family of costimulatory receptors, is expressed on activated T cells and plays a crucial role in modulating immune responses. ICOS, encoded by the ICOS gene, provides an essential costimulatory signal that promotes T cell activation, differentiation, and cytokine production. Upon activation by its ligand, ICOS ligand (ICOSLG or CD275), which is found on antigen-presenting cells (APCs) like B cells, dendritic cells, and macrophages, ICOS triggers intracellular signaling pathways that enhance T-cell effector functions. ICOS is crucial for both humoral and cell-mediated immunity. It enhances T-helper cell responses, particularly in the germinal centers of lymphoid tissues, where it influences B cell differentiation and supports antibody production. ICOS signaling also helps maintain the balance between effector and regulatory T cells, impacting inflammation control and immune tolerance. The ICOS/ICOSLG pathway is vital in the immune system's ability to fight infection and respond to vaccination, as well as in controlling immune tolerance to prevent autoimmune diseases.
Características del producto
category
Proteins and Peptides
origin
Rat
host
E. coli
immunogen target
Inducible T-Cell Costimulator (ICOS)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 12.2 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Gln39-Glu133 Tag: N-terminal His tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
ICOS
dry ice
No
availability
Shipped within 5-12 working days.
alias
Activation-inducible lymphocyte immunomediatory molecule,AILIM,CD278,CVID1,
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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
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