Rat Inducible T-Cell Co Stimulator Ligand (ICOSLG) ELISA Kit
552.5€ (96 tests)
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name
Rat Inducible T-Cell Co Stimulator Ligand (ICOSLG) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx255738
tested applications
ELISA
Description
Rat Inducible T-Cell Co Stimulator Ligand (ICOSLG) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat Inducible T-Cell Co Stimulator Ligand concentrations in serum, plasma and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Inducible T-Cell Co Stimulator Ligand (ICOSLG) |
| Reactivity | Rat |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 78 pg/ml - 5000 pg/ml |
| Sensitivity | 46.9 pg/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Serum, plasma and other biological fluids. |
| Availability | Shipped within 5-7 working days. The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | F1LVL2 |
| Alias | ICOS ligand, B7RP1,CD275,ICOSL,LICOS,B7RP-1,ICOS-L,IMD119,B7 homolog 2 |
| Background | Elisa kits for ICOSLG |
| Status | RUO |
| Note | Validity: The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
Inducible T-cell costimulator ligand (ICOSLG), also known as B7-H2 or CD275, is a critical immunoregulatory protein in the B7 family that provides costimulatory signals to T cells. ICOSLG serves as a ligand for ICOS (Inducible T-cell Costimulator), a receptor expressed on activated T cells. Through its interaction with ICOS, ICOSLG plays an essential role in modulating adaptive immune responses, particularly influencing T-cell differentiation, proliferation, and the formation of memory T cells. This interaction is crucial for both protective immunity and immune tolerance, enabling the immune system to respond robustly to pathogens while preventing autoimmunity. ICOSLG is primarily expressed on antigen-presenting cells (APCs), such as B cells, dendritic cells (DCs), macrophages, and certain epithelial cells in mucosal tissues. Its expression is inducible and can be upregulated during inflammation or immune activation by signals from pro-inflammatory cytokines like interferon-gamma (IFN-γ). The ICOS/ICOSLG axis is especially important for the regulation of germinal center formation in lymphoid tissues, where it facilitates B cell differentiation and antibody production. ICOSLG is also implicated in the maintenance of regulatory T cells (Tregs) and T-helper 17 (Th17) cells, thereby contributing to immune homeostasis and controlling inflammation.
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