Rat Hydroxycarboxylic Acid Receptor 2 (HCAR2) ELISA Kit

Pida mas información
935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for HCAR2
proveedor
Abbexareference
abx391466Tested Applications
ELISAreactivity
Ratstatus
RUOclonality
Descripción
Rat Hydroxycarboxylic Acid Receptor 2 (HCAR2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat HCAR2 concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
HCAR2, also known as GPR109A, is a G protein-coupled receptor activated by nicotinic acid (niacin) and endogenous metabolites such as β-hydroxybutyrate (BHB). It is highly expressed in adipose tissue, immune cells, and the gut, where it plays a pivotal role in lipid metabolism, inflammation, and energy homeostasis. In adipocytes, HCAR2 activation inhibits cAMP production via Gi/o proteins, leading to the suppression of lipolysis and reduced free fatty acid release, which lowers circulating triglyceride levels. HCAR2 also mediates anti-inflammatory effects in immune cells, particularly in macrophages, by inhibiting pro-inflammatory cytokine production and promoting anti-inflammatory pathways, making it a key target in atherosclerosis and inflammatory diseases. HCAR2 is activated during fasting or ketogenic states through β-hydroxybutyrate, linking it to metabolic adaptations and energy conservation. Dysregulation of HCAR2 is implicated in metabolic disorders, cardiovascular disease, and neuroinflammation. Niacin-based therapies targeting HCAR2 are used to improve lipid profiles and manage dyslipidemia, highlighting its clinical relevance.
Características del producto
category
ELISA Kits
immunogen target
Hydroxycarboxylic Acid Receptor 2 (HCAR2)
reactivity
Rat
test range
0.156 ng/ml - 10 ng/ml
sensitivity
< 0.07 ng/ml
assay type
Sandwich
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
alias
HCAR2,PUMAG,G-protein coupled receptor HM74A,Nicotinic acid receptor,Nic1,G protein-coupled receptor 109A,Niacr1,niacin receptor 1,HCA2,HM74a,HM74b,NIACR1,Puma-g,GPR109A
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
HCAR2
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
Quizá le pueda interesar
Hydroxycarboxylic Acid Receptor 2 (HCAR2) Antibody

proveedor
Abbexareference
abx214866Tested Applications
ELISA, IHCreactivity
Human, Mouse, Ratstatus
RUOclonality
PolyclonalHCAR2 Antibody is a Rabbit Polyclonal against HCAR2.
260€ (50 µl)
Ver másHydroxycarboxylic Acid Receptor 2 (HCAR2) Antibody

proveedor
Abbexareference
abx214867Tested Applications
ELISA, IHCreactivity
Human, Mouse, Ratstatus
RUOclonality
PolyclonalHCAR2 Antibody is a Rabbit Polyclonal against HCAR2.
260€ (50 µl)
Ver másHydroxycarboxylic Acid Receptor 2 (HCAR2) Antibody

proveedor
Abbexareference
abx376195Tested Applications
ELISA, WBreactivity
Humanstatus
RUOclonality
PolyclonalHydroxycarboxylic Acid Receptor 2 (HCAR2) Antibody is a Rabbit Polyclonal antibody against Hydroxycarboxylic Acid Recept...
351€ (100 µg)
Ver más