Rat Hydroxycarboxylic Acid Receptor 2 (HCAR2) ELISA Kit

Este producto es parte de HCAR - Hydroxy-Carboxylic Acid Receptor
Rat Hydroxycarboxylic Acid Receptor 2 (HCAR2) ELISA Kit

Pida mas información

935106861

info@markelab.com

Precio

715€ (96 tests)

Elisa kits for HCAR2

proveedor

Abbexa

reference

abx391466

Tested Applications

ELISA

reactivity

Rat

status

RUO

clonality

Descripción

Rat Hydroxycarboxylic Acid Receptor 2 (HCAR2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat HCAR2 concentrations in tissue homogenates, cell lysates and other biological fluids.


Background

HCAR2, also known as GPR109A, is a G protein-coupled receptor activated by nicotinic acid (niacin) and endogenous metabolites such as β-hydroxybutyrate (BHB). It is highly expressed in adipose tissue, immune cells, and the gut, where it plays a pivotal role in lipid metabolism, inflammation, and energy homeostasis. In adipocytes, HCAR2 activation inhibits cAMP production via Gi/o proteins, leading to the suppression of lipolysis and reduced free fatty acid release, which lowers circulating triglyceride levels. HCAR2 also mediates anti-inflammatory effects in immune cells, particularly in macrophages, by inhibiting pro-inflammatory cytokine production and promoting anti-inflammatory pathways, making it a key target in atherosclerosis and inflammatory diseases. HCAR2 is activated during fasting or ketogenic states through β-hydroxybutyrate, linking it to metabolic adaptations and energy conservation. Dysregulation of HCAR2 is implicated in metabolic disorders, cardiovascular disease, and neuroinflammation. Niacin-based therapies targeting HCAR2 are used to improve lipid profiles and manage dyslipidemia, highlighting its clinical relevance.

Características del producto

category

ELISA Kits


immunogen target

Hydroxycarboxylic Acid Receptor 2 (HCAR2)


reactivity

Rat


test range

0.156 ng/ml - 10 ng/ml


sensitivity

< 0.07 ng/ml


assay type

Sandwich


assay data

Quantitative


form

Lyophilized


detection method

Colorimetric


sample type

Tissue homogenates, cell lysates and other biological fluids.


size 1

96 tests


alias

HCAR2,PUMAG,G-protein coupled receptor HM74A,Nicotinic acid receptor,Nic1,G protein-coupled receptor 109A,Niacr1,niacin receptor 1,HCA2,HM74a,HM74b,NIACR1,Puma-g,GPR109A


storage

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.


or code

HCAR2


dry ice

No


note

This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.


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