Rat High Affinity Immunoglobulin Gamma Fc Receptor I / CD64 (FCGR1A) Protein (Active)
1079€ (100 µg)
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935106861
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name
Rat High Affinity Immunoglobulin Gamma Fc Receptor I / CD64 (FCGR1A) Protein (Active)
category
Proteins and Peptides
provider
Abbexa
reference
abx691620
tested applications
SDS-PAGE
Description
Rat CD64 Protein is a recombinant protein from Rat produced in HEK293 Cells. A DNA sequence encoding the rat FCGR1A (NP_001094306.1) extracellular domain (Met 1-Pro 285) was expressed, fused with a polyhistidine tag at the C-terminus.
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Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | High Affinity Immunoglobulin Gamma Fc Receptor I / CD64 (FCGR1A) |
| Host | HEK293 cells |
| Origin | Rat |
| Observed MW | Molecular Weight: 31.6 kDa Sequence Fragment: Met1-Pro285 Tag: C-terminal His tag Validity: The validity for this protein is 12 months. |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | |
| Tested Applications | SDS-PAGE |
| Buffer | Lyophilized from sterile PBS, pH 7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | A6K367, A0A0B4J2J0 |
| Gene ID | 295279 |
| NCBI Accession | NP_001094306.1 |
| Alias | CD64,FCG1,FCRI,CD64A,FCGR1,IGFR1,FcgammaRI,High affinity immunoglobulin gamma Fc receptor I,IgG Fc receptor I,Fc-gamma RIA |
| Background | Protein FCGR1A |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
FCGR1A (Fc gamma receptor Ia), also known as CD64, is a high-affinity receptor for the Fc region of immunoglobulin G (IgG) antibodies. It plays a crucial role in immune responses by binding to the Fc portion of IgG, mediating various immune functions such as phagocytosis, antibody-dependent cellular cytotoxicity (ADCC), and immune complex clearance. FCGR1A is predominantly expressed on monocytes, macrophages, and dendritic cells, as well as on neutrophils during inflammatory responses. The interaction between FCGR1A and IgG antibodies bridges innate and adaptive immunity, facilitating the elimination of pathogens and other foreign particles. It is also critical in the regulation of immune responses by modulating inflammatory signals. FCGR1A is involved in the recognition of opsonized particles, initiating signaling cascades that result in cytokine production, phagocytosis, and the clearance of immune complexes.
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