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Rat Heparin Cofactor II (SERPIND1) Protein
Pida mas información
935106861
info@markelab.com
Precio
237.5€ (10 µg)
Protein SERPIND1
proveedor
Abbexareference
abx067067Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Recombinant Heparin Cofactor II (SERPIND1) is a recombinant Rat protein produced in E. coli using Prokaryotic expression.
Background
SERPIND1 encodes Heparin Cofactor II (HCII), a serine protease inhibitor (serpin) that plays a critical role in the regulation of coagulation. It shares functional similarities with antithrombin (SERPINC1), particularly in inhibiting thrombin, a key enzyme in the coagulation cascade. However, HCII exhibits a more specialized function as its activity is highly dependent on heparin-like glycosaminoglycans (GAGs), particularly dermatan sulfate, and to a lesser extent, heparin. HCII's involvement in thrombin inhibition and its activation through GAGs have made it an essential component in controlling clot formation and preventing thrombosis, particularly in vascular tissue. HCII deficiency has been linked to a predisposition for thromboembolic disorders and cardiovascular diseases.
Características del producto
category
Proteins and Peptides
origin
Rat
host
E. coli
immunogen target
Heparin Cofactor II (HCII)
host
E. coli
conjugation
Unconjugated
form
Lyophilized
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
1 mg
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
SERPIND1
dry ice
No
availability
Shipped within 5-7 working days.
alias
HC2,LS2,HCF2,HCII,HLS2,THPH10,D22S673,Heparin cofactor 2,Heparin cofactor II,Protease inhibitor leuserpin-2,Serpin D1
uniprot id
note
This product is for research use only. <p></p> Not for human consumption, cosmetic, therapeutic or diagnostic use.
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