Rat Heparin Cofactor II (SERPIND1) Protein
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935106861
info@markelab.com
Precio
247€ (10 µg)
Protein SERPIND1
proveedor
Abbexareference
abx067067Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Recombinant Heparin Cofactor II (SERPIND1) is a recombinant Rat protein produced in a Prokaryotic expression system (E. coli).
Background
SERPIND1 encodes Heparin Cofactor II (HCII), a serine protease inhibitor (serpin) that plays a critical role in the regulation of coagulation. It shares functional similarities with antithrombin (SERPINC1), particularly in inhibiting thrombin, a key enzyme in the coagulation cascade. However, HCII exhibits a more specialized function as its activity is highly dependent on heparin-like glycosaminoglycans (GAGs), particularly dermatan sulfate, and to a lesser extent, heparin. HCII's involvement in thrombin inhibition and its activation through GAGs have made it an essential component in controlling clot formation and preventing thrombosis, particularly in vascular tissue. HCII deficiency has been linked to a predisposition for thromboembolic disorders and cardiovascular diseases.
Características del producto
category
Proteins and Peptides
origin
Rat
host
E. coli
immunogen target
Heparin Cofactor II (HCII)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 28.1 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Glu25-Asp235 Tag: N-terminal His tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
SERPIND1
dry ice
No
availability
Shipped within 5-7 working days.
alias
HC2,LS2,HCF2,HCII,HLS2,THPH10,D22S673,Heparin cofactor 2,Heparin cofactor II,Protease inhibitor leuserpin-2,Serpin D1
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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