Rat Gonadotropin Releasing Hormone Receptor (GnRHR) Protein
1872€ (1 mg)
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name
Rat Gonadotropin Releasing Hormone Receptor (GnRHR) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx653623
tested applications
WB, SDS-PAGE
Description
Rat Gonadotropin Releasing Hormone Receptor (GnRHR) Protein is a Recombinant Rat protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Gonadotropin Releasing Hormone Receptor (GnRHR) |
| Host | E. coli |
| Origin | Rat |
| Conjugation | Unconjugated |
| Observed MW | Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Please enquire. Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 90% |
| Size 1 | 1 mg |
| Size 2 | 5 mg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 1-2 months. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | GNRHR,luteinizing hormone-releasing hormone (LHRH) receptor,GNRHR1,LHRH receptor,Type I GnRHR,gnRH receptor,GnRH-R,GnRH I receptor,GnRHR,luliberin receptor ,LHRHR, GRHR, HH7, LHRHR,GnRH1 receptor |
| Background | Protein GNRHR |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
GNRHR is a G protein-coupled receptor (GPCR) expressed primarily in the anterior pituitary gland, where it binds gonadotropin-releasing hormone (GnRH). Upon activation, GNRHR stimulates the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which regulate gonadal function, steroidogenesis, and gametogenesis. GNRHR signaling occurs through Gq/11 proteins, activating phospholipase C (PLC), increasing intracellular calcium, and stimulating protein kinase C (PKC). It plays a central role in reproductive physiology, controlling the menstrual cycle in females and testosterone production in males. Mutations in GNRHR are linked to disorders such as hypogonadotropic hypogonadism, characterized by delayed puberty and infertility. GNRHR is also expressed in extra-pituitary tissues and certain cancers, such as breast, prostate, and ovarian cancers, where it regulates cell proliferation and survival. Therapeutically, GnRH agonists and antagonists are used to treat hormone-dependent conditions, including infertility, endometriosis, and cancers. GNRHR remains a critical target in reproductive medicine and oncology.
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