Rat Gamma-Glutamyl Hydrolase (GGH) ELISA Kit
715€ (96 tests)
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935106861
info@markelab.com
name
Rat Gamma-Glutamyl Hydrolase (GGH) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx391375
tested applications
ELISA
Description
Rat Gamma-Glutamyl Hydrolase (GGH) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat GGH concentrations in serum, plasma, tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Gamma-Glutamyl Hydrolase (GGH) |
| Reactivity | Rat |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Sensitivity | < 0.094 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Serum, plasma, tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-12 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q62867 |
| Gene ID | 25455 |
| Alias | GATD10,GH,Gamma-Glu-X carboxypeptidase |
| Background | Elisa kits for GGH |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
Gamma-Glutamyl Hydrolase (GGH) is an enzyme involved in folate metabolism that catalyzes the hydrolysis of polyglutamated folates into monoglutamates, which are required for folate transport and cellular uptake GGH plays a key role in regulating intracellular folate levels, which are critical for DNA synthesis, repair, and methylation processes Dysregulation of GGH activity can affect cellular proliferation and is associated with conditions such as cancer, where altered folate metabolism promotes tumor growth and progression GGH expression has been linked to resistance to antifolate chemotherapeutic agents like methotrexate, as increased GGH activity reduces the retention of polyglutamated drugs, decreasing their efficacy GGH also participates in redox regulation, as folate metabolism contributes to cellular antioxidant defense pathways Studies highlight its involvement in conditions like neural tube defects and anemia due to its critical role in folate homeostasis Emerging evidence suggests that GGH activity may serve as a biomarker for cancer therapy response and other folate-related metabolic disorders
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