Rat Fibroblast Growth Factor Receptor Like Protein 1 (FGFRL1) Protein
234€ (10 µg)
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Name
Rat Fibroblast Growth Factor Receptor Like Protein 1 (FGFRL1) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx066618
Tested Applications
WB, SDS-PAGE
Description
Rat Fibroblast Growth Factor Receptor Like Protein 1 (FGFRL1) is a recombinant Rat protein expressed in E. coli.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Fibroblast Growth Factor Receptor Like Protein 1 (FGFRL1) |
| Host | E. coli |
| Assay Type | Activity: Not tested Sequence Fragment: Val164-Thr368 Tag: N-terminal His tag |
| Origin | Rat |
| Conjugation | Unconjugated |
| Observed MW | Calculated MW: 26.6 kDa |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q7TQM3 |
| Alias | FHFR,FGFR5,FGFR-5,Fibroblast growth factor receptor 5,FGFR-like protein,FGF homologous factor receptor,FGF receptor-like protein 1 |
| Background | Protein FGFRL1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. Concentration: Prior to lyophilization: 200 µg/ml |
Background
Fibroblast growth factor receptor like 1 (FGFRL1) FGFRL1 is a unique member of the FGFR family that lacks the intracellular tyrosine kinase domain, distinguishing it from other FGFRs. FGFRL1 contains an extracellular ligand-binding domain similar to other FGFRs, capable of binding FGFs and interacting with heparan sulfate proteoglycans. However, instead of activating intracellular signaling cascades, FGFRL1 is thought to act as a decoy receptor, modulating FGF availability and signaling. FGFRL1 plays a role in skeletal development, cartilage formation, and kidney morphogenesis, as evidenced by its high expression in these tissues during development. Mutations or dysregulation of FGFRL1 have been linked to skeletal abnormalities, including craniosynostosis and cartilage defects. Additionally, FGFRL1 may influence cellular adhesion and migration through interactions with extracellular matrix components. Its distinctive lack of kinase activity highlights its role as a regulatory rather than a signaling receptor in FGF-mediated processes.
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