Rat Fibroblast Growth Factor Receptor 1 (FGFR1) ELISA Kit
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935106861
info@markelab.com
Precio
687.5€ (96 tests)
Elisa Kits FGFR1
proveedor
Abbexareference
abx155526Tested Applications
ELISAreactivity
Ratstatus
RUOclonality
Descripción
Rat Fibroblast Growth Factor Receptor 1 (FGFR1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat FGFR1 concentrations in tissue homogenates, cell lysates and other biological fluids. This assay has high sensitivity and excellent specificity for detection of FGFR1 (FGFR1)No significant cross-reactivity or interference between FGFR1 (FGFR1) and analogues was observed.
Background
Fibroblast growth factor receptor 1 (FGFR1) FGFR1 is a transmembrane tyrosine kinase receptor that binds fibroblast growth factors (FGFs), playing a critical role in cellular proliferation, differentiation, and survival. FGFR1 consists of an extracellular ligand-binding domain composed of three immunoglobulin-like loops, a single transmembrane helix, and an intracellular tyrosine kinase domain. Upon FGF binding, FGFR1 undergoes dimerization and autophosphorylation, triggering downstream signaling pathways such as the MAPK, PI3K-AKT, and PLCγ pathways. FGFR1 is essential in embryonic development, angiogenesis, and tissue repair, and its dysregulation is implicated in various cancers, including lung and breast cancer, where aberrant FGFR1 activation promotes tumor growth and survival. FGFR1 is also involved in skeletal development, and mutations in the FGFR1 gene can lead to developmental disorders such as Pfeiffer syndrome. Its widespread expression in multiple tissues highlights its diverse biological roles.
Características del producto
category
ELISA Kits
immunogen target
Fibroblast Growth Factor Receptor 1 (FGFR1)
reactivity
Rat
test range
0.312 ng/ml - 20 ng/ml
sensitivity
< 0.13 ng/ml
assay type
Sandwich
assay data
Quantitative
detection method
Colorimetric
sample type
Tissue homogenates,Cell lysates,Other biological fluids
size 1
96 tests
size 2
5 × 96 tests
size 3
10 × 96 tests
alias
H2,H3,H4,5,CEK,FLG,BFGFR,N-SAN,CD331,FGFR-1,Proto-oncogene c-Fgr,Fms-like tyrosine kinase 2,Pfeiffer syndrome
storage
Enviado a 4 °C. Una vez recibido, almacene el kit de acuerdo con las instrucciones citadas en el manual del kit
or code
FGFR1
dry ice
No
uniprot id
note
This product is for research use only. <p></p> The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. <p></p> Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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