Rat Epithelial Discoidin Domain-Containing Receptor 1 (DDR1) Protein

Este producto es parte de DDR1 - discoidin domain receptor tyrosine kinase 1
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1079€ (100 µg)

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935106861
info@markelab.com
name
Rat Epithelial Discoidin Domain-Containing Receptor 1 (DDR1) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx692466
tested applications
SDS-PAGE

Description

Rat DDR1 Kinase Protein is a recombinant protein from Rat produced in HEK293 Cells. A DNA sequence encoding the rat DDR1 (Q6MG19) (Met1-Thr413) was expressed with a polyhistidine tag at the C-terminus.

Documents del producto

Instrucciones
Data sheet
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Product specifications

Category
Proteins and Peptides
Immunogen Target
DDR1 Kinase
Host
HEK293 cells
Origin
Rat
Observed MW
Molecular Weight: 45.3 kDa
Sequence Fragment: Met1-Thr413
Tag: C-terminal His tag
Validity: The validity for this protein is 12 months.
Expression
Recombinant
Purity
> 95% (SDS-PAGE)
Size 1
100 µg
Form
 
Tested Applications
SDS-PAGE
Buffer
Lyophilized from sterile PBS, pH 7.4.
Availability
Shipped within 5-15 working days.
Storage
Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
Q6MG19
Alias
Epithelial discoidin domain-containing receptor 1,Epithelial discoidin domain receptor 1,CA, DDR,NEP,HGK2,PTK3,RTK6,TRKE,CD167,EDDR1,MCK10,NTRK4,PTK3A,Discoidin receptor tyrosine kinase,Mammary carcinoma kinase 10
Background
Protein DDR1
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

Discoidin domain receptor 1 (DDR1) is a receptor tyrosine kinase (RTK) that uniquely binds to collagens, distinguishing it from other RTKs that are primarily activated by growth factors or hormones. DDR1 is encoded by the DDR1 gene located on chromosome 6p21.3 in humans and is widely expressed across various tissues, including the kidneys, brain, lungs, and reproductive organs. DDR1 has critical roles in cell adhesion, proliferation, migration, and differentiation, primarily through its unique capacity to interact with the extracellular matrix (ECM), particularly collagens. As a collagen-binding receptor, DDR1 is involved in cellular responses to structural changes in the ECM, making it essential in tissue remodeling, wound healing, and organ development. DDR1 has become increasingly significant in the context of cancer biology due to its involvement in cell adhesion and motility, which are critical for metastasis. It is also implicated in fibrotic diseases, where it contributes to tissue stiffness and fibrosis, and in immune response modulation. The discovery of DDR1 has broadened the understanding of RTKs, as it revealed a subset of kinases that function primarily through interactions with ECM proteins, underscoring its role in both physiological and pathological conditions.

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