Rat Endoribonuclease ZC3H12A (ZC3H12A) ELISA Kit

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715€ (96 tests)

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935106861
info@markelab.com
name
Rat Endoribonuclease ZC3H12A (ZC3H12A) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx257463
tested applications
ELISA

Description

Rat Endoribonuclease ZC3H12A (ZC3H12A) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat Endoribonuclease ZC3H12A concentrations in tissue homogenates, cell lysates and other biological fluids.

Documents del producto

Instrucciones
Data sheet
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Product specifications

Category
ELISA Kits
Immunogen Target
Endoribonuclease ZC3H12A (ZC3H12A)
Reactivity
Rat
Detection Method
Colorimetric
Assay Data
Quantitative
Assay Type
Sandwich
Test Range
0.156 ng/ml - 10 ng/ml
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Size 1
96 tests
Form
Lyophilized
Tested Applications
ELISA
Sample Type
Tissue homogenates, cell lysates and other biological fluids.
Availability
Shipped within 5-15 working days. The validity for this kit is 6 months.
Storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry Ice
No
UniProt ID
A0JPN4
Gene ID
313587
Background
Elisa kits for ZC3H12A
Status
RUO
Note
Validity: The validity for this kit is 6 months.
This product is for research use only.   The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments.   Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

Descripción

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Endoribonuclease involved in various biological functions such as cellular inflammatory response and immune homeostasis, glial differentiation of neuroprogenitor cells, cell death of cardiomyocytes, adipogenesis and angiogenesis. Functions as an endoribonuclease involved in mRNA decay(PubMed:19909337). Modulates the inflammatory response by promoting the degradation of a set of translationally active cytokine-induced inflammation-related mRNAs, such as IL6 and IL12B, during the early phase of inflammation(PubMed:26320658). Prevents aberrant T-cell-mediated immune reaction by degradation of multiple mRNAs controlling T-cell activation, such as those encoding cytokines(IL6 and IL2), cell surface receptors(ICOS, TNFRSF4 and TNFR2) and transcription factor(REL)(By similarity). Self regulates by destabilizing its own mRNA(By similarity). Cleaves mRNA harboring a stem-loop(SL), often located in their 3'-UTRs, during the early phase of inflammation in a helicase UPF1-dependent manner(PubMed:19909337, PubMed:26320658, PubMed:26134560, PubMed:22561375). Plays a role in the inhibition of microRNAs(miRNAs) biogenesis(PubMed:22055188). Cleaves the terminal loop of a set of precursor miRNAs(pre-miRNAs) important for the regulation of the inflammatory response leading to their degradation, and thus preventing the biosynthesis of mature miRNAs(PubMed:22055188). Plays also a role in promoting angiogenesis in response to inflammatory cytokines by inhibiting the production of antiangiogenic microRNAs via its anti-dicer RNase activity(PubMed:24048733). Affects the overall ubiquitination of cellular proteins(By similarity). Positively regulates deubiquitinase activity promoting the cleavage at 'Lys-48'-and 'Lys-63'-linked polyubiquitin chains on TNF receptor-associated factors(TRAFs), preventing JNK and NF-kappa-B signaling pathway activation, and hence negatively regulating macrophage-mediated inflammatory response and immune homeostasis(By similarity). Induces also deubiquitination of the transcription factor HIF1A, probably leading to its stabilization and nuclear import, thereby positively regulating the expression of proangiogenic HIF1A-targeted genes(PubMed:24048733). Involved in a TANK-dependent negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta(IL1B) stimulation or upon DNA damage(PubMed:25861989). Prevents stress granule(SGs) formation and promotes macrophage apoptosis under stress conditions, including arsenite-induced oxidative stress, heat shock and energy deprivation(By similarity). Plays a role in the regulation of macrophage polarization; promotes IL4-induced polarization of macrophages M1 into anti-inflammatory M2 state(By similarity). May also act as a transcription factor that regulates the expression of multiple genes involved in inflammatory response, angiogenesis, adipogenesis and apoptosis(PubMed:16574901, PubMed:18364357). Functions as a positive regulator of glial differentiation of neuroprogenitor cells through an amyloid precursor protein(APP)-dependent signaling pathway(PubMed:19185603). Attenuates septic myocardial contractile dysfunction in response to lipopolysaccharide(LPS) by reducing I-kappa-B-kinase(IKK)-mediated NF-kappa-B activation, and hence myocardial proinflammatory cytokine production(By similarity). (Microbial infection) Exhibits broad antiviral activity by cleaving viral RNAs(PubMed:23355615). Binds to Japanese encephalitis virus(JEV) and dengue virus(DEN) RNAs(PubMed:23355615). Exhibits antiviral activity against HIV-1 in lymphocytes by decreasing the abundance of HIV-1 viral RNA species(PubMed:24191027).

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