Rat Disrupted In Schizophrenia 1 (DISC1) Protein

Este producto es parte de DISC1 Scaffold Protein
Rat Disrupted In Schizophrenia 1 (DISC1) Protein

Pida mas información

935106861

info@markelab.com

Precio

247€ (10 µg)

Protein DISC1

proveedor

Abbexa

reference

abx066353

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Recombinant Disrupted In Schizophrenia 1 (DISC1) is a recombinant Rat protein produced in a Prokaryotic expression system (E. coli).


Background

Disrupted in schizophrenia 1 (DISC1) is a scaffolding protein with diverse roles in neurodevelopment, synaptic function, and adult neurogenesis. Originally identified in a Scottish family with a high incidence of schizophrenia, DISC1 has since been implicated in several psychiatric disorders, including bipolar disorder and major depression. DISC1 interacts with multiple molecular partners, influencing signaling pathways involved in neuronal proliferation, migration, and axonal growth. Additionally, it regulates mitochondrial function and intracellular trafficking. Dysfunctional DISC1 has been associated with structural brain abnormalities, synaptic deficits, and altered neuronal connectivity, which are common features in neuropsychiatric disorders. The multifaceted roles of DISC1 in cellular processes and its potential as a biomarker or therapeutic target underscore its significance in neuroscience and psychiatry research.

Características del producto

category

Proteins and Peptides


origin

Rat


host

E. coli


immunogen target

Disrupted In Schizophrenia 1 (DISC1)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 24.1 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Glu151-Gln340 Tag: N-terminal His tag


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

DISC1


dry ice

No


availability

Shipped within 5-7 working days.


alias

DISC1, C1orf136, SCZD9, disrupted in schizophrenia 1, DISC1 scaffold protein


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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Tested Applications

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reactivity

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reference

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reactivity

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