Rat Dipeptidyl Peptidase 4 / CD26 (DPP4) Protein
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935106861
info@markelab.com
Precio
234€ (10 µg)
Protein DPP4
proveedor
Abbexareference
abx066345Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Dipeptidyl Peptidase IV (DPP4) is a recombinant Rat protein produced in a Prokaryotic expression system (E. coli).
Background
Dipeptidyl peptidase 4 (DPP4), also known as CD26, is a transmembrane glycoprotein and serine protease that plays a significant role in regulating glucose metabolism, immune function, and cell signaling. It is expressed on the surface of various cell types, including epithelial cells, endothelial cells, and immune cells such as T cells and B cells. DPP4 is widely known for its role in glucose homeostasis through its enzymatic activity, where it deactivates incretin hormones like glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). These hormones promote insulin release in response to meals, and their inactivation by DPP4 reduces insulin secretion, thereby impacting blood sugar levels. Beyond its metabolic functions, DPP4 also participates in various immune regulatory pathways. As CD26, it is involved in T-cell activation and co-stimulation. DPP4 is linked to inflammatory processes and certain cancers, particularly due to its enzymatic activity and role in regulating immune responses. Additionally, the soluble form of DPP4 (sDPP4), which circulates in the plasma, plays a role in systemic metabolic and immune regulation.
Características del producto
category
Proteins and Peptides
origin
Rat
host
E. coli
immunogen target
Dipeptidyl Peptidase 4 / CD26 (DPP4)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 16.0 kDa Observed MW (SDS-PAGE): 15 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Ser638-Arg767 Tag: N-terminal His tag
expression
Recombinant
purity
> 90%
buffer
Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
DPP4
dry ice
No
availability
Shipped within 5-7 working days.
alias
CD26,ADABP,ADCP2,DPPIV,TP103,Dipeptidyl peptidase 4,Adenosine deaminase complexing protein 2,ADCP-2,Dipeptidyl peptidase IV,T-cell activation antigen CD26
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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