Rat Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4) Protein
923€ (100 µg)
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935106861
info@markelab.com
name
Rat Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx692107
tested applications
SDS-PAGE
Description
Rat CTLA-4 Protein is a recombinant protein from Rat produced in HEK293 Cells. A DNA sequence encoding the rat Ctla4 (NP_113862.1) (Met1-Asp161) was expressed with a polyhistidine tag at the C-terminus.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | CTLA-4 |
| Host | HEK293 cells |
| Origin | Rat |
| Observed MW | Molecular Weight: 15.2 kDa Sequence Fragment: Met1-Asp161 Tag: C-terminal His tag Validity: The validity for this protein is 12 months. |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Size 1 | 100 µg |
| Form | |
| Tested Applications | SDS-PAGE |
| Buffer | Lyophilized from sterile PBS, pH 7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| NCBI Accession | NP_113862.1 |
| Alias | Cytotoxic T-lymphocyte protein 4,CD,GSE,GRD4,ALPS5,CD152,Cytotoxic T-lymphocyte-associated antigen 4,CTLA-4,IDDM12,CELIAC3, |
| Background | Protein CTLA4 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Cytotoxic T-lymphocyte associated protein 4 (CTLA-4), encoded by the CTLA4 gene on chromosome 2, is an essential immune checkpoint receptor primarily expressed on activated T cells and regulatory T cells (Tregs). CTLA-4 plays a crucial role in maintaining immune homeostasis by delivering inhibitory signals to downregulate T cell activation and proliferation. This receptor functions by binding to the ligands CD80 (B7-1) and CD86 (B7-2), which are expressed on antigen-presenting cells (APCs). By inhibiting excessive immune responses, CTLA-4 prevents autoimmunity and maintains immune tolerance to self-antigens. CTLA-4 is the first immune checkpoint to have been targeted for immunotherapy, exemplified by the development of the monoclonal antibody ipilimumab, which blocks CTLA-4 to boost anti-tumor immune responses. Given its significance in regulating immune responses, CTLA-4 is a focus of research in fields ranging from oncology to autoimmune disorders.
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