Rat Tissue Factor (F3) Protein
377€ (20 µg)
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935106861
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name
Rat Tissue Factor (F3) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx694317
tested applications
SDS-PAGE
Description
Tissue Factor (F3) protein is a recombinant Rat protein expressed in HEK293 cells.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Tissue Factor (F3) |
| Host | HEK293 cells |
| Assay Type | Activity: Not tested Sequence Fragment: Met1-Glu252 Tag: C-terminal His tag |
| Origin | Rat |
| Observed MW | Calculated MW: 27.61 kDa Observed MW (SDS-PAGE): 49 kDa |
| Expression | Recombinant |
| Purity | >95% (SDS-PAGE) |
| Size 1 | 20 µg |
| Size 2 | 100 µg |
| Size 3 | 500 µg |
| Size 4 | 1 mg |
| Form | Lyophilized |
| Tested Applications | SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 5% - 8% Trehalose, Mannitol and 0.01% Tween-80. |
| Availability | Shipped within 5-15 working days. |
| Storage | Storage: Store lyophilized between -20 °C and -80°C. Stability: Stable when stored reconstituted at 2-8°C for up to 1 week. Reconstituted aliquots are stable at -20°C for up to 3 months. Shelf Life: 12 months. |
| Dry Ice | No |
| UniProt ID | P42533 |
| Gene ID | 25584 |
| Alias | TF,TFA,CD142,Coagulation factor III,Thromboplastin |
| Background | Protein F3 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. Reconstitute in sterile H2O. Do not vortex. |
Descripción
Coagulation Factor III, also known as Tissue Factor (F3), is a critical glycoprotein in the initiation of the extrinsic pathway of the coagulation cascade. It acts as a receptor and cofactor for Factor VIIa, forming a complex that activates Factor X, which in turn leads to thrombin generation and clot formation. Tissue Factor is highly expressed in subendothelial tissues and is exposed upon vascular injury, where it serves as the primary trigger for hemostasis. Beyond its role in coagulation, F3 also participates in various signaling pathways, influencing inflammation, angiogenesis, and cancer progression through its interaction with protease-activated receptors (PARs). Dysregulation of Tissue Factor expression is associated with pathological conditions such as thrombosis, atherosclerosis, and malignancies. The study of F3 and its interactions, including its structure and binding properties, is crucial for developing targeted anticoagulant therapies and understanding its role in disease mechanisms. Its activity is often analyzed using advanced biochemical assays to elucidate its functions in both normal and pathological states.
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