Rat Cluster of Differentiation 3d (CD3D) Protein
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Description
Cluster Of Differentiation 3d (CD3d) is a recombinant Rat protein produced in a Prokaryotic expression system (E. coli).
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Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Cluster of Differentiation 3d (CD3D) |
| Host | E. coli |
| Origin | Rat |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 10.9 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Phe22-Gly106 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P04235 |
| Alias | T3D,IMD19,CD3DELTA,CD3-DELTA,T-cell surface glycoprotein CD3 delta chain,T-cell receptor T3 delta chain |
| Background | Protein CD3D |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
CD3D, the delta subunit of the T-cell receptor (TCR) complex, plays a critical role in T-cell development and activation, which are essential components of the adaptive immune system. The TCR complex is responsible for recognizing antigens presented by major histocompatibility complex (MHC) molecules on the surface of antigen-presenting cells (APCs), allowing T-cells to initiate immune responses against pathogens. The CD3D subunit, along with other CD3 subunits (CD3E, CD3G, and CD3Z), functions as part of the CD3 complex, which couples with the TCR α/β heterodimer to mediate signal transduction following antigen recognition. The CD3D gene, located on chromosome 11q23, encodes the CD3δ chain, a 20-25 kDa protein essential for the assembly and function of the TCR complex. The CD3 complex, including the CD3D subunit, is expressed in all T lymphocytes and plays a vital role in transmitting signals from the extracellular environment to the interior of the cell, initiating downstream signaling cascades essential for T-cell activation, differentiation, and survival.
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CD3D antibody
The protein encoded by this gene is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding different isoforms have been found for this gene. Other variants may also exist, but the full-length natures of their transcripts has yet to be defined.
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