Rat Cholecystokinin A Receptor (CCKAR) ELISA Kit

Product specifications

ELISA Kits

Cholecystokinin A Receptor (CCKAR)

Rat

Colorimetric

Quantitative

Sandwich

0.156 ng/ml - 10 ng/ml

< 0.06 ng/ml

Optimal dilutions/concentrations should be determined by the end user.

96 tests

5 × 96 tests

10 × 96 tests

Lyophilized

ELISA

Tissue homogenates and other biological fluids.

Shipped within 5-7 working days. The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request.

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.

No

CCKAR,CCK-1R,CCK-A,CCK1-R,CCK1R,CCKRA,CCK1-R,cholecystokinin receptor type A,cholecystokinin-1 receptor

Elisa kits for CCKAR

RUO

Validity: The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request.
This product is for research use only.   The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments.   Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

Descripción

CCKAR is a G protein-coupled receptor (GPCR) predominantly expressed in the gastrointestinal tract, pancreas, and brain, where it binds the peptide hormone cholecystokinin (CCK) with high affinity. It regulates digestive processes by stimulating gallbladder contraction, pancreatic enzyme secretion, and gastric motility. In the brain, CCKAR is involved in satiety signaling, regulating appetite and feeding behavior by modulating neuronal pathways in the hypothalamus and brainstem. Its activation triggers downstream signaling pathways such as phospholipase C (PLC), calcium mobilization, and protein kinase C (PKC), leading to cellular responses like smooth muscle contraction and enzyme secretion. CCKAR is implicated in metabolic disorders, including obesity, where dysregulated signaling contributes to appetite dysregulation and energy imbalance. It also plays a role in anxiety and mood disorders, as CCK signaling interacts with neurotransmitter systems like dopamine and serotonin. In cancer, CCKAR overexpression has been observed in pancreatic and gastrointestinal cancers, where it enhances cell proliferation and survival. Pharmacological targeting of CCKAR is being explored for obesity, gastrointestinal disorders, and certain cancers. Overall, CCKAR is essential for gastrointestinal function, appetite regulation, and metabolic homeostasis.

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