Rat CD97 Antigen (ADGRE5) Protein

Este producto es parte de ADGRE - Adhesion G protein-coupled receptor E
Rat CD97 Antigen (ADGRE5) Protein
247€ (10 µg)

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Name
Rat CD97 Antigen (ADGRE5) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx167749
Tested Applications
WB, SDS-PAGE

Description

Rat Cluster Of Differentiation 97 Protein is a recombinant Rat protein expressed in E. coli.

Documentos del producto

Instrucciones
Data sheet
Descargar

Especificaciones del producto

Category
Proteins and Peptides
Immunogen Target
CD97 Antigen (ADGRE5)
Host
E. coli
Assay Type
Activity: Not tested
Sequence Fragment: Lys191-Asn304
Tag: N-terminal His tag and GST tag
Origin
Rat
Conjugation
Unconjugated
Observed MW
Calculated MW: 42.3 kDa  Observed MW (SDS-PAGE): 44 kDa
Expression
Recombinant
Purity
> 97%
Size 1
10 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
500 µg
Form
Lyophilized
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300.
Availability
Shipped within 5-7 working days.
Storage
Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles.
Dry Ice
No
Alias
ADGRE5,CD97,BL-Ac (F2),CD97,TM7LN1
Background
Protein ADGRE5
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Concentration: Prior to lyophilization: 200 µg/ml

Background

Adhesion G protein-coupled receptor E5 (ADGRE5), also known as CD97, is a member of the adhesion GPCR family and plays an essential role in cell-cell and cell-matrix interactions. ADGRE5 is highly expressed in immune cells, including macrophages, neutrophils, and T-cells, as well as in endothelial and epithelial cells, where it mediates adhesion, migration, and cellular activation. It is a heterodimeric receptor that interacts with extracellular matrix proteins and cellular ligands such as CD55 (decay-accelerating factor), enabling immune surveillance and inflammation regulation. ADGRE5 is upregulated during inflammation, infection, and cancer progression, contributing to leukocyte recruitment, angiogenesis, and metastasis. Dysregulation of ADGRE5 is associated with autoimmune diseases, such as rheumatoid arthritis and inflammatory bowel disease, and its expression levels are linked to tumor aggressiveness in cancers like glioblastoma and colorectal cancer. Therapeutic targeting of ADGRE5 is being explored as a strategy to modulate immune responses and inhibit tumor metastasis by disrupting its signaling pathways and ligand interactions.

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