Rat CD97 Antigen (ADGRE5) Protein
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Description
Cluster Of Differentiation 97 Protein is a recombinant Rat protein expressed in E. coli.
Documents del producto
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | CD97 Antigen (ADGRE5) |
| Host | E. coli |
| Origin | Rat |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 42.3 kDa Observed MW (SDS-PAGE): 44 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Lys191-Asn304 Tag: N-terminal His tag and GST tag |
| Expression | Recombinant |
| Purity | > 97% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | ADGRE5,CD97,BL-Ac (F2),CD97,TM7LN1 |
| Background | Protein ADGRE5 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Adhesion G protein-coupled receptor E5 (ADGRE5), also known as CD97, is a member of the adhesion GPCR family and plays an essential role in cell-cell and cell-matrix interactions. ADGRE5 is highly expressed in immune cells, including macrophages, neutrophils, and T-cells, as well as in endothelial and epithelial cells, where it mediates adhesion, migration, and cellular activation. It is a heterodimeric receptor that interacts with extracellular matrix proteins and cellular ligands such as CD55 (decay-accelerating factor), enabling immune surveillance and inflammation regulation. ADGRE5 is upregulated during inflammation, infection, and cancer progression, contributing to leukocyte recruitment, angiogenesis, and metastasis. Dysregulation of ADGRE5 is associated with autoimmune diseases, such as rheumatoid arthritis and inflammatory bowel disease, and its expression levels are linked to tumor aggressiveness in cancers like glioblastoma and colorectal cancer. Therapeutic targeting of ADGRE5 is being explored as a strategy to modulate immune responses and inhibit tumor metastasis by disrupting its signaling pathways and ligand interactions.
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This gene encodes a member of the EGF-TM7 subfamily of adhesion G protein-coupled receptors, which mediate cell-cell interactions. These proteins are cleaved by self-catalytic proteolysis into a large extracellular subunit and seven-span transmembrane subunit, which associate at the cell surface as a receptor complex. The encoded protein may play a role in cell adhesion as well as leukocyte recruitment, activation and migration, and contains multiple extracellular EGF-like repeats which mediate binding to chondroitin sulfate and the cell surface complement regulatory protein CD55. Expression of this gene may play a role in the progression of several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms with 3 to 5 EGF-like repeats have been observed for this gene. This gene is found in a cluster with other EGF-TM7 genes on the short arm of chromosome 19.
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