Rat CD97 Antigen (ADGRE5) CLIA Kit

Este producto es parte de ADGRE - Adhesion G protein-coupled receptor E
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643.5€ (96 tests)

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935106861
info@markelab.com
name
Rat CD97 Antigen (ADGRE5) CLIA Kit
category
CLIA Kits
provider
Abbexa
reference
abx196828
tested applications
CLIA

Description

Rat Cluster of Differentiation 97 (CD97) Chemiluminescent Immunoassay (CLIA) Kit is a Chemiluminescent Immunoassay (CLIA) kit against Cluster of Differentiation 97 (CD97).

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
CLIA Kits
Immunogen Target
CD97 Antigen (ADGRE5)
Reactivity
Rat
Detection Method
Chemiluminescent
Assay Data
Quantitative
Assay Type
Sandwich
Test Range
7.81 pg/ml - 500 pg/ml
Sensitivity
4.69 pg/ml
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Size 1
96 tests
Form
Lyophilized
Tested Applications
CLIA
Sample Type
Serum, plasma and other biological fluids.
Availability
Shipped within 5-12 working days.
Storage
 Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry Ice
No
Alias
ADGRE5,CD97,BL-Ac (F2),CD97,TM7LN1
Background
CLIA Kits ADGRE5
Status
RUO
Note
The validity for this kit is 6 months.   This product is for research use only.   The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments.   Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

Descripción

Adhesion G protein-coupled receptor E5 (ADGRE5), also known as CD97, is a member of the adhesion GPCR family and plays an essential role in cell-cell and cell-matrix interactions. ADGRE5 is highly expressed in immune cells, including macrophages, neutrophils, and T-cells, as well as in endothelial and epithelial cells, where it mediates adhesion, migration, and cellular activation. It is a heterodimeric receptor that interacts with extracellular matrix proteins and cellular ligands such as CD55 (decay-accelerating factor), enabling immune surveillance and inflammation regulation. ADGRE5 is upregulated during inflammation, infection, and cancer progression, contributing to leukocyte recruitment, angiogenesis, and metastasis. Dysregulation of ADGRE5 is associated with autoimmune diseases, such as rheumatoid arthritis and inflammatory bowel disease, and its expression levels are linked to tumor aggressiveness in cancers like glioblastoma and colorectal cancer. Therapeutic targeting of ADGRE5 is being explored as a strategy to modulate immune responses and inhibit tumor metastasis by disrupting its signaling pathways and ligand interactions.

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This gene encodes a member of the EGF-TM7 subfamily of adhesion G protein-coupled receptors, which mediate cell-cell interactions. These proteins are cleaved by self-catalytic proteolysis into a large extracellular subunit and seven-span transmembrane subunit, which associate at the cell surface as a receptor complex. The encoded protein may play a role in cell adhesion as well as leukocyte recruitment, activation and migration, and contains multiple extracellular EGF-like repeats which mediate binding to chondroitin sulfate and the cell surface complement regulatory protein CD55. Expression of this gene may play a role in the progression of several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms with 3 to 5 EGF-like repeats have been observed for this gene. This gene is found in a cluster with other EGF-TM7 genes on the short arm of chromosome 19.

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