Rat CD70 Antigen / TNFSF7 (CD70) Protein (Active)
663€ (50 µg)
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Name
Rat CD70 Antigen / TNFSF7 (CD70) Protein (Active)
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx693206
Tested Applications
SDS-PAGE
Description
Rat CD70 Protein is a recombinant protein from Rat produced in HEK293 Cells. A DNA sequence encoding the rat CD70 (NP_001100348) (Gln46-Pro195) was expressed, fused with a polyhistidine tag at the N-terminus.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | CD70 |
| Host | HEK293 cells |
| Assay Type | Activity: Active Sequence Fragment: Gln46-Pro195 Tag: N-terminal His tag |
| Origin | Rat |
| Observed MW | 18.9 kDa |
| Expression | Recombinant |
| Purity | > 90% (SDS-PAGE) |
| Size 1 | 50 µg |
| Form | Lyophilized |
| Tested Applications | SDS-PAGE |
| Buffer | Lyophilized from sterile PBS, pH 7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Storage: Store lyophilized between -20 °C and -80°C. Stability: Stable when stored reconstituted at 2-8°C for up to 1 week. Reconstituted aliquots are stable at -20°C for up to 3 months. Shelf Life: 12 months. |
| Dry Ice | No |
| NCBI Accession | NP_001100348 |
| Alias | CD27L,LPFS3,CD27-L,CD27LG,TNFSF7,TNLG8A,CD70 antigen,CD27 ligand |
| Background | Protein CD70 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. Endotoxin Level: < 1.0 EU per µg of the protein as determined by the LAL method. |
Background
CD70, also known as TNFSF7 (Tumor Necrosis Factor Superfamily Member 7), is a transmembrane glycoprotein that belongs to the tumor necrosis factor (TNF) ligand superfamily. It is primarily expressed on the surface of activated immune cells, including T cells, B cells, dendritic cells (DCs), and natural killer (NK) cells. The expression of CD70 is tightly regulated and is typically transient, occurring upon immune cell activation, particularly during the adaptive immune response. CD70 plays a crucial role in immune cell interactions, contributing to T cell proliferation, differentiation, and the development of memory T cells. CD70 exerts its effects by binding to its receptor, CD27, which is a member of the TNF receptor superfamily. CD27 is constitutively expressed on naïve T cells, memory T cells, and NK cells, and its interaction with CD70 initiates intracellular signaling pathways that enhance immune activation and memory formation. This CD70-CD27 interaction is critical for effective immune responses, particularly during viral infections, tumor immunity, and in the context of autoimmune diseases.
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