Rat CD2 Associated Protein (CD2AP) Protein

Background

CD2-associated protein (CD2AP) is a cytoskeletal adaptor protein that plays a crucial role in cellular signaling and structural organization, particularly in podocytes within the kidney glomerulus. CD2AP interacts with various proteins to regulate actin cytoskeleton dynamics, supporting cell morphology and adhesion. It is a scaffolding protein that links membrane proteins, such as nephrin and other slit diaphragm proteins, to intracellular signaling pathways, ensuring the integrity of the filtration barrier in the kidney. Dysfunctions or mutations in the CD2AP gene are strongly associated with proteinuric kidney diseases, including focal segmental glomerulosclerosis (FSGS). Beyond its role in the kidney, CD2AP is implicated in immune synapse formation due to its interaction with the CD2 receptor on T cells, facilitating immune cell communication. CD2AP's functions in vesicular trafficking and endocytosis are also essential for cellular homeostasis. This protein is increasingly studied in the context of neurodegenerative diseases, such as Alzheimer's disease, where it is believed to impact amyloid precursor protein processing and autophagy pathways.