Rat CD2 Associated Protein (CD2AP) ELISA Kit
715€ (96 tests)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Rat CD2 Associated Protein (CD2AP) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx505754
tested applications
ELISA
Description
Rat CD2 Associated Protein (CD2AP) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat CD2-associated protein concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | CD2 Associated Protein (CD2AP) |
| Reactivity | Rat |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | F1LRS8 |
| Alias | CD2AP, CMS |
| Background | Elisa kits for CD2AP |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
CD2-associated protein (CD2AP) is a cytoskeletal adaptor protein that plays a crucial role in cellular signaling and structural organization, particularly in podocytes within the kidney glomerulus. CD2AP interacts with various proteins to regulate actin cytoskeleton dynamics, supporting cell morphology and adhesion. It is a scaffolding protein that links membrane proteins, such as nephrin and other slit diaphragm proteins, to intracellular signaling pathways, ensuring the integrity of the filtration barrier in the kidney. Dysfunctions or mutations in the CD2AP gene are strongly associated with proteinuric kidney diseases, including focal segmental glomerulosclerosis (FSGS). Beyond its role in the kidney, CD2AP is implicated in immune synapse formation due to its interaction with the CD2 receptor on T cells, facilitating immune cell communication. CD2AP's functions in vesicular trafficking and endocytosis are also essential for cellular homeostasis. This protein is increasingly studied in the context of neurodegenerative diseases, such as Alzheimer's disease, where it is believed to impact amyloid precursor protein processing and autophagy pathways.
Related Products
anti- Cd2ap antibody
Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation. May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell. May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis.
Ver Producto
CD2 Associated Protein (CD2AP) Antibody
CD2AP Antibody is a Rabbit Polyclonal Antibody against CD2AP.
Ver Producto