Calcitonin gene-related peptide, (CGRP) is a neuropeptide secreted and stored in the nervous system. In humans, CGRP exists in two forms: CGRP alpha (α-CGRP or CGRP I), a 37-amino acid neuropeptide produced through alternative splicing of the CALCA gene (CALC1) and CGRP beta (β-CGRP or CGRP II), which is encoded by a separate, nearby gene known as CALCB (CALC2). These two forms differ only by three amino acids.N-terminal disulfide bond and an amidated C-terminus and allows CGRP to bind to its receptorCGRP has a protective role in various cardiovascular diseases and its involvement in migraines has also been proven. Additionally, it has been discovered that CGRP serves as a crucial link between the nervous system and the skeletal muscle system. CGRP plays a multifaceted role by promoting osteogenesis, inhibiting bone resorption, facilitating vascular growth, and regulating the immune microenvironment.
El péptido relacionado con el gen de la calcitonina (CGRP) es un neuropéptido secretado y almacenado en el sistema nervioso. En humanos, el CGRP existe en dos formas: CGRP alfa (α-CGRP o CGRP I), un neuropéptido de 37 aminoácidos producido mediante corte y empalme alternativo del gen CALCA (CALC1) y CGRP beta (β-CGRP o CGRP II), que está codificado por un gen cercano e independiente conocido como CALCB (CALC2). Estas dos formas se diferencian sólo por tres aminoácidos. Enlace disulfuro N-terminal y un extremo C amidado que permite que el CGRP se una a su receptor. El CGRP tiene un papel protector en diversas enfermedades cardiovasculares y también se ha demostrado su implicación en las migrañas. Además, se ha descubierto que el CGRP sirve como vínculo crucial entre el sistema nervioso y el sistema del músculo esquelético. El CGRP desempeña un papel multifacético al promover la osteogénesis, inhibir la resorción ósea, facilitar el crecimiento vascular y regular el microambiente inmunológico.
ELISA Kits
rat
15.625-1000pg/ml
Sandwich ELISA, Double Antibody
Quantitative
Colorimetric
Serum,Plasma,Tissue homogenates,Other biological fluids
96T
Calca|CALC1|CALCA|Calcitonin 1|CGRP|CT|Katacalcin|PCT|Preprocalcitonin|ATP2B2plasma membrane calcium ATPase|ATPase|Ca++ transporting|plasma membrane 4|DKFZp686G08106|DKFZp686M088|EC 3.6.3|EC 3.6.3.8|Matrix-remodeling-associated protein 1|matrix-remodelling associated 1|MXRA1|Plasma membrane calcium ATPase isoform 4|plasma membrane calcium pump|Plasma membrane calcium pump isoform 4|plasma membrane calcium-transporting ATPase 4|PMCA4b|PMCA4PMCA4x|sarcolemmal calcium pump
2-8 °C for 6 months
Calca
Calcitonin (CALCA) Antibody is a Rabbit Polyclonal against Calcitonin (CALCA).
262.5€ (100 µl)
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