Rat BCL2 Antagonist/Killer 1 (BAK1) ELISA Kit
546€ (96 tests)
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name
Rat BCL2 Antagonist/Killer 1 (BAK1) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx256729
tested applications
ELISA
Description
Rat BCL2 Antagonist/Killer 1 (BAK1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat BCL2 Antagonist/Killer 1 concentrations in serum, plasma and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | BCL2 Antagonist/Killer 1 (BAK1) |
| Reactivity | Rat |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.78 ng/ml - 50 ng/ml |
| Sensitivity | 0.47 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Serum, plasma and other biological fluids. |
| Availability | Shipped within 5-7 working days. The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q9JK59 |
| Gene ID | 116502 |
| Alias | BAK,BAK-LIKE,BCL2L7,CDN1,Bcl-2 homologous antagonist/killer,Apoptosis regulator BAK,Bcl-2-like protein 7,Bcl2-L-7 |
| Background | Elisa kits for BAK1 |
| Status | RUO |
| Note | Validity: The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
BCL2 antagonist/killer 1 (BAK1) is a pro-apoptotic member of the Bcl-2 family of proteins, which regulate cell death pathways and cellular survival BAK1 plays a critical role in mitochondrial-mediated apoptosis, where it promotes the release of cytochrome c from the mitochondria, triggering the activation of caspase enzymes that lead to programmed cell death It functions as a key mediator of apoptosis in response to cellular stress, DNA damage, and oncogenic signaling, making it essential for maintaining cellular homeostasis and preventing the accumulation of damaged cells BAK1's activation is tightly regulated by anti-apoptotic proteins like Bcl-2, and its dysregulation is commonly associated with cancer, where loss of BAK1 function allows tumor cells to evade apoptosis, promoting tumor growth and resistance to chemotherapy Studies have also linked BAK1 to neurodegenerative diseases, where its dysregulation may contribute to neuronal loss and dysfunction Additionally, BAK1 has been implicated in immune responses, where it regulates T-cell homeostasis and immune cell survival, underscoring its broader role in cellular death and immune regulation
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anti- BAK antibody
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress.
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