Rat B-Cell CLL/Lymphoma 2 Like Protein 2 (Bcl2L2) Protein

Este producto es parte de BCL2L2 - BCL2 like 2
Rat B-Cell CLL/Lymphoma 2 Like Protein 2 (Bcl2L2) Protein
208€ (10 µg)

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Name
Rat B-Cell CLL/Lymphoma 2 Like Protein 2 (Bcl2L2) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx652642
Tested Applications
WB, SDS-PAGE

Description

Rat B-Cell CLL/Lymphoma 2 Like Protein 2 (Bcl2L2) Protein is a recombinant Rat protein expressed in E. coli.

Documentos del producto

Instrucciones
Data sheet
Descargar

Especificaciones del producto

Category
Proteins and Peptides
Immunogen Target
B-Cell CLL/Lymphoma 2 Like Protein 2 (Bcl2L2)
Host
E. coli
Assay Type
Activity: Not tested
Sequence Fragment: Please enquire.
Tag: N-terminal His tag
Origin
Rat
Conjugation
Unconjugated
Expression
Recombinant
Purity
> 90%
Size 1
10 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
500 µg
Form
Lyophilized
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
Availability
Shipped within 5-7 working days.
Storage
Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles.
Dry Ice
No
Alias
Bcl-2-like protein 2,BCLW,BCL-W,PPP1R51,BCL2-L-2,Apoptosis regulator Bcl-W
Background
Protein BCL2L2
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Concentration: Prior to lyophilization: 200 µg/ml

Background

BCL2 like 2 (BCL2L2), also known as BCL-W, is another anti-apoptotic protein in the Bcl-2 family, crucial for regulating cell survival by preventing mitochondrial apoptosis BCL2L2 interacts with pro-apoptotic proteins such as Bax and Bak, preventing their activation and the subsequent release of cytochrome c from the mitochondria BCL2L2’s role in inhibiting apoptosis is particularly important in cells that undergo high levels of stress, such as hematopoietic cells and certain neuronal populations Dysregulation of BCL2L2 has been associated with cancer, where its overexpression allows tumor cells to evade apoptosis, contributing to tumor survival, metastasis, and resistance to chemotherapy In addition, BCL2L2 is involved in maintaining tissue homeostasis and immune cell survival, influencing T-cell differentiation and activation Studies have suggested that BCL2L2 could be targeted for therapeutic purposes in both cancer and autoimmune diseases, where modulating cell death pathways can improve patient outcomes

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