Rat B-Cell Activation Factor Receptor / BAFFR (TNFRSF13C) Protein

Background

TNFRSF13C, also known as the B-cell activating factor receptor (BAFF-R), is a critical receptor involved in the regulation of B cell survival and maturation within the immune system. It belongs to the tumor necrosis factor receptor superfamily (TNFRSF), with BAFF-R specifically binding BAFF (B-cell activating factor), also known as TNFSF13B. BAFF-R signaling is essential for the differentiation of B cells and their progression through developmental stages, playing a crucial role in both innate and adaptive immunity. Dysfunction in TNFRSF13C signaling has been implicated in immune-related disorders, including autoimmune diseases and immunodeficiencies. Genetic mutations or dysregulation in BAFF-R and BAFF signaling pathways are associated with conditions such as Systemic Lupus Erythematosus (SLE) and Common Variable Immunodeficiency (CVID), as they can lead to abnormal B cell activity, autoreactivity, and altered antibody production. This receptor is also studied as a therapeutic target for autoimmune diseases, with strategies aimed at modulating BAFF levels to control B cell activity.